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The Brief

The most important stories for you to know today
  • FDA panel supports widening access

    Topline:

    Advisers to the Food and Drug Administration voted in favor of easing regulation of popular peptides. The recommendations could pave the way for specialized pharmacies to produce them in the U.S.

    Why it matters: Currently, these peptides can't be made in the U.S., except for research purposes, leading many peptide users to buy unvetted substances sold online, with disclaimers such as "for research use only" and "not for human consumption."

    By narrow margins, the panel voted in favor of all but one. The FDA isn't required to follow advisory committee recommendations but typically does.

    A slate of popular peptide therapies has won the backing of a key advisory panel to the federal government — a step that could eventually open up broader access to the experimental drugs.

    In a marathon two-day meeting last week, the panel of doctors, academics and pharmacists recommended the Food and Drug Administration reclassify almost all of the compounds under consideration so that specialized pharmacies in the U.S. could begin offering them.

    Seven different peptide therapies — none of which are FDA-approved drugs — were under consideration.

    Currently, these peptides can't be made in the U.S., except for research purposes, leading many peptide users to buy unvetted substances sold online, with disclaimers such as "for research use only" and "not for human consumption."

    By narrow margins, the panel voted in favor of all but one. The FDA isn't required to follow advisory committee recommendations but typically does.

    The outcome represents a win for Health Secretary Robert F. Kennedy Jr., who has publicly supported peptide therapies, and the broader wellness and longevity industry, which stands to profit substantially.

    These peptides are promoted for a wide range of uses and are often taken together, including for injury recovery, muscle growth and fat loss, improving athletic performance, enhancing metabolism and more.

    If the agency takes the panel's recommendations, clinicians could have the ability to prescribe six peptide therapies: BPC-157, MOTS-c, KPV, TB-500, Epitalon and Semax.

    A compound called Emideltide, sometimes used for insomnia, was the only one to receive a down vote.

    The panel's endorsement of peptides was a striking rejection of the FDA's stance against them.

    While the level of evidence for each compound varies, all of them lack the kind of large, well-controlled trials in humans that are necessary to establish safety and effectiveness, which is required for drug approvals. Peptides are strings of amino acids — smaller than a protein — that often act as signaling molecules in our bodies and carry out many critical functions.

    They can be synthesized and delivered as drugs, often by injection. Some of those, like insulin, are naturally occurring in the body. Others are modified versions, as with the blockbuster GLP-1 obesity drugs.

    Scientists for the agency spoke extensively about the lack of reliable data for any of the seven peptides before the committee. They advised the panel to vote no.

    In some cases, they couldn't find any published clinical studies in humans — and there were safety concerns like the potential to encourage cancer growth or to trigger a massive immune response.

    A "foundational challenge" was simply defining the substances, because the chemical composition for peptides labeled with the same name varied considerably, explained FDA official Russell Wesdyk.

    "You will see many, many different forms," he said. "We can't create quality standards until we actually know what it is."

    The divide among the experts on the panel was a study in contrasts.

    Ahead of the meeting, eight new members were appointed. Most have ties to the peptide industry and include physicians who work for medical practices and companies that promote them.

    In almost all cases, they voted in favor of lifting restrictions.

    A spokesperson for the Department of Health and Human Services pushed back on criticism about potential conflicts of interest and said all underwent the standard ethics and vetting process.

    "I think it's about patient access," said Dr. Asare Christian, one of the panel members who runs a Pennsylvania-based clinic that advertises peptide protocols and hormone optimization.

    That sentiment was echoed throughout the many hours of public comment.

    Compounding pharmacies, large telehealth providers and others from the industry underscored the perils of the unregulated marketplace, with some offering anecdotes of patients obtaining unmarked vials from sketchy suppliers.

    "What we are advocating for is not the Wild West," said Brigham Buhler, who runs a telehealth company that offers hormone optimization and peptides and is an ally of Secretary Kennedy.

    "What we are advocating for is to slow down or shut down the gray and black market and to allow patients to have a safe and effective manufacturing process," he told the panel.

    But some panelists were skeptical of that argument.

    "I'm concerned that we are responding to market-induced demand rather than a decision based in solid science," Dr. Elizabeth Rebello, an anaesthesiologist at the University of Texas MD Anderson Cancer Center, commented after casting a no vote.

    The FDA committee was tasked with reviewing data that supports using these peptides to treat a variety of specific conditions, such as BPC-157 for treating ulcerative colitis, an inflammatory bowel disease.

    However, if the FDA ultimately reclassifies them and they are produced by compounding pharmacies in the U.S., clinicians would have discretion to write prescriptions outside of those narrow indications.

    During the meeting, industry groups — and some on the panel — repeatedly criticized the FDA presentations for not reflecting more recent scientific data on the substances, including results from other human studies that had been submitted ahead of time.

    FDA staff said they had considered everything submitted by the meeting deadline and would still take new information into account as they weigh next steps.

    The decision to place the products on the FDA's official list for compounding doesn't come close to the standards for drug approval, but some worry that nuance will not be clear to the public, which may not be aware of the limited data for humans.

    "I think this endorsement can be potentially harmful and I cannot in good conscience vote yes," said Dr. Brian Lee, a member of the panel and an associate professor at the Keck School of Medicine of USC.

    If the FDA moves to reclassify the peptides so that compounding pharmacies can make them, it will be through a formal rulemaking process that could stretch into next year or 2028. There is a possibility that Kennedy could invoke special authority to make them available sooner.

    The panel is scheduled to meet again in February to consider additional peptide therapies.
    Copyright 2026 NPR

  • Service from South OC to Oceanside suspended
    A passing train along the coastline.
    Metrolink’s Orange County service between the Laguna Niguel/Mission Viejo and Oceanside stations will be temporarily suspended starting Monday, Oct. 26, through Friday, Oct. 30, due to high tide forecasts.

    Topline:

    Metrolink’s Orange County service between the Laguna Niguel/Mission Viejo and Oceanside stations will be temporarily suspended next week, starting Monday, Oct. 26, through Friday, Oct. 30.

    What lines will run? Orange County Line trains will operate only between L.A. Union Station and the Laguna Niguel/Mission Viejo Station. According to Metrolink, alternate transportation such as buses will not be available.

    Why now? A coastal flood warning is in effect for the entire Orange and San Diego coastline Sunday through Thursday. “Astronomical” high tides could create significant coastal flooding starting Sunday, according to the National Weather Service. Morning high tides could reach nearly 7 feet Saturday morning and are likely to exceed 7.5 or 8 feet by Monday.

    Officials said: “The temporary service adjustment is intended to minimize the potential for widespread delays and cancellations if coastal conditions disrupt rail operations,” Metrolink officials wrote in an announcement Thursday. “This shift will also reduce competing rail traffic and shorten potential weather-related delays for other carriers, including Amtrak Pacific Surfliner and freight trains, that operate along the beachfront corridor near San Clemente.”

    Background: The service suspension is along the troubled rail corridor from South Orange County to the San Diego County line. Erosion and landslides along the coastal rail have caused disruptions since 2021.

    Dig deeper … The OC Transit Authority is in the middle of creating its 30-year plan for the coastal rail. 

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  • E-bike criminal charges
    More than a dozen e-bikes parked in front of a metal fence with a sign on it that reads "Newport Theatre Arts Center."
    Students at Ensign Intermediate School have been parking their e-bikes in the neighborhood since the district outlawed them on elementary and middle school campuses.

    Topline:

    The Orange County District Attorney’s Office filed charges Wednesday against six parents and one relative of children involved in illegal e-motorcycle use. O.C. District Attorney Todd Spitzer joined AirTalk, LAist 89.3's daily news show, to talk about the charges and rising e-bike-related incidents.

    What he's saying: "We have about a 430% increase in emergency room visits by young people today, underage minors, who are being injured as a result of these e-bikes," Spitzer said, referring to incidents in Southern California.

    A growing issue: Spitzer pointed out that Wednesday’s charges are the latest in a growing number of cases involving e-bikes, including one incident that resulted in a 13-year-old rider’s death.

    Why charge the parents? Spitzer clarified that parents are not being charged with a crime just for giving their child an e-bike. "We're filing when the adult who's responsible for the actions of that child has additional special knowledge that their kid is a danger to the community and, in most cases, to themselves," he said, such as a history of reckless riding or knowledge of illegal modifications.

    Example: In the case of the 13-year-old who died after crashing his e-motorcycle, his father could face up to six years in prison.

    Listen to the full conversation:

    Listen 9:51
    Orange County D.A. announces charges tied to e-bike usage

  • Book vendors, panels and more return Nov. 14
    A line of books sit spine-up on a table.
    The third annual OC Book Fair returns to Old Town Tustin on Nov. 14.

    Topline:

    The third annual OC Book Fair returns to Old Town Tustin on Nov. 14 with bookish activities, local authors, shopping and more. A portion of El Camino Real will be closed for the free event.

    What to expect: Attendees will be able to watch author talks, get books signed, participate in community roundtables and more. The fair lineup features indie bookstores, including local shops like Arvida Book Co., Heartbound Book Shop and the Untold Story Bookstore.

    What you need to know: The fair will take place from 10 a.m. to 5 p.m. along El Camino Real between Main and Second streets and on Third Street between C Street and Prospect Avenue.

    What about parking? Free street parking will be available throughout Old Town Tustin, as well as at the Tustin Public Library and the Civic Center. More free parking will also be available at the C Street Parking Structure, located behind 158 W. Main St.

    For more info: Visit the OC Book Fair site.

  • Becerra and Hilton's plans unclear
    Xavier Becerra, left, and Steve Hilton, right, stand at separate white podiums on a CNN debate stage. Becerra has a medium skin tone and wears thin-framed glasses, a dark suit, white shirt and maroon tie, while Hilton has a light skin tone and a short light beard and wears a navy jacket over an open-collared white shirt.
    From left, gubernatorial candidates Xavier Becerra and Steve Hilton, during CNN’s California Gubernatorial Debate at CNN’s studio in Burbank on Sept. 30, 2026

    Topline:

    In September, Gov. Gavin Newsom unveiled what is likely one of the last large climate announcements of his tenure: California will move forward with linking its decade-old carbon market with a newly formed market in Washington state, aiming to merge it with the market California already shares with Quebec. Newsom said California was “choosing certainty, partnership, and clean energy” amid a stream of federal climate policy rollbacks. As Newsom leaves his post, many policy and climate experts say the adjustments to the program put California’s climate goals further out of reach. The program provides billions of dollars in funding for climate and other programs.

    Why it matters: With little talk of climate policy in the governor's race, Californians are largely left guessing about how Steve Hilton or Xavier Becerra would handle the program or California’s broader climate ambitions. The Becerra campaign did not respond to multiple emailed requests for comment. Hilton told CalMatters he would move to suspend the carbon market — which he called “a disaster of a program” — entirely.

    What's at stake: Whoever wins in November can appoint a handful of new members to the California Air Resources Board, which has to finish writing the linkage rules and will propose the budget that leans on carbon market revenue. The next governor will also help decide how aggressively California leads on climate, after a year of mixed signals about where the program is headed.

    The backstory: Twenty years ago, lawmakers made California the first state to mandate broad cuts in greenhouse gas emissions with AB 32, the landmark carbon emissions reduction law, which authorized the subsequent creation of a market. The law requires the program to be as cost-effective as possible while maximizing benefits to the state’s economy.

    In September, Gov. Gavin Newsom unveiled what is likely one of the last large climate announcements of his tenure: California will move forward with linking its decade-old carbon market with a newly formed market in Washington state, aiming to merge it with the market California already shares with Quebec.

    Newsom said California was “choosing certainty, partnership, and clean energy” amid a stream of federal climate policy rollbacks.

    But the announcement didn’t distract environmental advocates from the sting of a challenging year back home for the so-called “cap-and-invest” program. As Newsom leaves his post, many policy and climate experts say the adjustments to the program put California’s climate goals further out of reach. The program provides billions of dollars in funding for climate and other programs.

    Yet with little talk of climate policy in the governor's race, Californians are largely left guessing about how Steve Hilton or Xavier Becerra would handle the program or California’s broader climate ambitions. The Becerra campaign did not respond to multiple emailed requests for comment. Hilton told CalMatters he would move to suspend the carbon market — which he called “a disaster of a program” — entirely.

    Twenty years ago, lawmakers made California the first state to mandate broad cuts in greenhouse gas emissions with AB 32, the landmark carbon emissions reduction law, which authorized the subsequent creation of a market. The law requires the program to be as cost-effective as possible while maximizing benefits to the state’s economy.

    Whoever wins in November can appoint a handful of new members to the California Air Resources Board, which has to finish writing the linkage rules and will propose the budget that leans on carbon market revenue. The next governor will also help decide how aggressively California leads on climate, after a year of mixed signals about where the program is headed.

    “It's really set up the politics of these issues to get worse and not better over time, and that is the problem that is being tossed like a live grenade into the lap of the next governor,” said Danny Cullenward, an economist who sits on an advisory committee focused on the carbon market.

    A question of climate leadership

    In May, a process to reauthorize the keystone climate program ended with a controversial agreement that the Legislative Analyst’s Office projects will roughly halve annual auction revenue, offering about $2 billion less in funding for priority environmental programs while opening a separate pool of free permits for polluters that pledge to invest in decarbonization, valued at as much as $4 billion.

    Oil companies fought the initial cap-and-invest reauthorization proposal, arguing it would encourage companies to leave the state or further increase fuel prices. The California Air Resources Board, which manages the program, said the increased allowances it eventually approved were meant to balance affordability and economic uncertainty alongside emissions targets. In an email, a board spokesperson said the new incentives would not have any impact on the market’s auction revenue. (The Western States Petroleum Association, which represents refiners in the state, declined an interview for this story.)

    The concern comes as California prepares to elect its next governor and nears its own 2030 target to reduce greenhouse gas emissions 40% below 1990 levels, on its way to zeroing out emissions by 2045.

    “This is not a question anymore of whether or not we'll reach the target. This is a guarantee that we won't,” said Katie Valenzuela, a consultant for Communities for a Better Environment who previously co-chaired an environmental justice committee that advised regulators on the state’s program.

    State officials have long framed cap-and-invest as a backstop, keeping the state on track for its climate targets by ratcheting down the emissions limit even if other programs fall short. Advocates worry the changes will have a chilling effect rather than signal the market’s long-term strength, just as California loses ground to federal rollbacks.

    “It is going to become very difficult for us to say we are a climate leader when we are visibly missing our targets,” Cullenward said.

    Others remain more optimistic. Cap-and-invest is one tool in California’s toolbox, even if this year dulled it. Meredith Fowlie, an economist at the University of California, Berkeley, said the program is not optimal but has done the basics of its job: sending a price signal to drive down emissions while raising revenues for important programs.

    Linking with Washington’s market will strengthen California’s program overall, air board Chair Lauren Sanchez wrote to Newsom in September. In addition to creating a larger market with more credits available to industries in both states, the link is expected to raise carbon credit prices in California, where recent auctions have yielded prices at state minimums. A connected market could also lower prices in Washington, making the state’s more stringent program less lucrative. Low prices reduce the program’s revenues and starve polluting industries’ incentive to invest in lowering emissions.

    Regulators have not yet established a rulemaking timeline for the linkage process, a spokesperson for the board told CalMatters, but the board expects the joint market to begin operating next year.

    Chloe Ames, policy adviser at NextGen Policy, an organization founded by former gubernatorial candidate Tom Steyer, called linkage a strong step forward. The group is disappointed by the other changes made to cap-and-invest this year, she said, and will keep urging the legislature to adjust the industry incentives and California’s next governor to take climate seriously.

    “It's been more challenging for us to say that we're a climate leader, and that's why we need to step up,” Ames said. “In this work, what are you going to do other than to be hopeful?”

    Kicking the can

    Since the market began, revenue has funded a wide range of priorities, including job training, clean energy and affordable housing. Managing those investments, alongside costs to Californians and emissions cuts, has been a balancing act — one the next governor will inherit, Fowlie said. “Some of those objectives are potentially in tension,” she said. “A sole focus on designing the program to meet our greenhouse gas reductions misses this really important larger picture that this program is about more than that.”

    The legislature approved the program’s reauthorization and the state’s air regulators lay out its rules, but a governor has influence over how that process plays out and can exert his own priorities, Cullenward said.

    Beyond the carbon market, governors have wider latitude: Newsom has used his executive authority on wildfires, water shortages and clean energy.

    In the governor’s race, neither candidate has centered climate in his campaign. In their one debate, both candidates steered a question about climate change’s impacts toward affordability concerns, offering little detail on the actual climate policies they favor.

    “I think it's fair to say that climate probably isn't the top priority of either one,” said Barry Vesser, the chief operating officer at the Climate Center, a California environmental group that opposed this year’s changes to the carbon market.

    Becerra’s campaign website emphasizes affordability in climate policy. He has faced criticism for defending Chevron and for accepting large oil and gas donations. As attorney general, though, he defended the state’s carbon program in court, arguing that “carbon pollution knows no borders” and promising that California would fight the first Trump administration’s rollbacks.

    Hilton has rallied against California’s Democratic establishment, and he told CalMatters he would aim to de-bloat the bureaucracy guiding the state’s climate policies. He likened the market’s recent programmatic changes to “rearranging deck chairs on the Titanic.” Hilton, who considers himself an environmentalist, has argued for redirecting resources from current climate programs and wildfire mitigation toward management of the state’s natural lands. He also wants to rework renewable incentives to create “a level playing field” for technologies like rooftop solar, hydropower and geothermal energy. His strategy, he claims, will reduce economic burdens for Californians while exceeding the state’s climate targets.

    The relative lack of attention to climate policy is a missed opportunity, according to Valenzuela and Vesser. They see a chance for the next governor to more directly and publicly connect climate programs to affordability, a key concern for likely voters and an issue on which Becerra and Hilton agree.

    Ultimately, the race’s rhetoric has advocates like Valenzuela “freaked out.” She points to a “huge chasm” between present reality and the policies that would put California on the right track. The state has little time left for the aggressive action its climate ambitions require, she and other advocates say, and it’s time to start dealing in reality.

    “There's not many more governors left we can kick the can to before that bill comes due,” Cullenward said.

    This article was originally published on CalMatters and was republished under the Creative Commons Attribution-NonCommercial-NoDerivatives license.