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The Brief

The most important stories for you to know today
  • July 4 travelers face steep rates
    A blue sign show three different prices for gas.
    Gas prices at a gas station in Sacramento on March 19. Prices at the pump continue to rise amid the escalating conflict involving the United States, Israel and Iran.

    Topline:

    Drivers are heading into the Fourth of July weekend with national gas prices at their highest level for the holiday in four years. In California, where prices remain well above the national average, the state’s petroleum watchdog has flagged a separate problem — one that goes beyond the state’s shrinking refinery capacity and isolated fuel market.

    Why it matters: The last week of May was the Memorial Day holiday, when the Iran-war price spike was near its peak. Chevron stations in California charged an average of $6.34 a gallon that week — the highest of any brand tracked in the state, and 44 cents above the average unbranded station, those that sell gas without a major oil-company logo.

    Why now: The finding came from California’s gasoline watchdog, a unit inside the state Energy Commission called the Division of Petroleum Market Oversight, which delivered a presentation to a state Senate committee on June 3.

    The context: The presentation showed branded stations charged more than unbranded ones in California — a bigger gap than in the rest of the country — and identified major brands’ grip on the retail market as a driver. California can now see into its gasoline market as never before. But its laws may be fighting the wrong problem.

    Read on... for more on what's driving the high prices.

    Drivers are heading into the Fourth of July weekend with national gas prices at their highest level for the holiday in four years. In California, where prices remain well above the national average, the state’s petroleum watchdog has flagged a separate problem — one that goes beyond the state’s shrinking refinery capacity and isolated fuel market.

    The last week of May was the Memorial Day holiday, when the Iran war price spike was near its peak. Chevron stations in California charged an average of $6.34 a gallon that week — the highest of any brand tracked in the state and 44 cents above the average unbranded station, those that sell gas without a major oil company logo.

    The finding came from California’s gasoline watchdog, a unit inside the state Energy Commission called the Division of Petroleum Market Oversight, which delivered a presentation to a state Senate committee June 3.

    The presentation showed branded stations charged more than unbranded ones in California — a bigger gap than in the rest of the country — and identified major brands’ grip on the retail market as a driver.

    California can now see into its gasoline market as never before. But its laws may be fighting the wrong problem.

    The state’s existing gas-price oversight laws, pushed by Gov. Gavin Newsom earlier in his term, centered on emergency price hikes, refinery outages and California-specific supply disruptions. Newsom backed away from some of the most aggressive measures last year after two California refineries announced closures. Economists say the harder target is a retail market where prices can be shaped by algorithms, supplier contracts and the buying power of the biggest brands.

    As another holiday weekend approaches, and the worst of the Iran-war price spike appears to be subsiding, the debate has moved into court and the Legislature.

    A federal class-action lawsuit filed last week in Sacramento accuses Kalibrate, a fuel-pricing software company, and several major gasoline retailers of using algorithms and competitor data to keep California pump prices artificially high, citing a state law that took effect this year barring algorithmic price coordination. Kalibrate has denied the allegations.

    The lawsuit names several major retailers, including Marathon, which operates ARCO stations; 7-Eleven; WalMart, including Sam’s Club; Circle K and Albertson’s.

    The complaint alleges that even small increases in California’s gas market can make huge differences, with every one cent increase costing drivers $134 million a year. It also cites research that using the software can increase prices by 6 cents per gallon, and up to 30 cents per gallon when many stations in an area are using the software.

    The suit taps into a longstanding theory: Severin Borenstein, an energy economist at UC Berkeley, has pointed to what he calls a “mystery gasoline surcharge” — the part of California’s high prices left unexplained after taxes, environmental programs and production costs are accounted for — that shows up after gas leaves the refinery.

    “The real question is, do they have evidence that the company or the gas stations are using the company to coordinate their activities?” Borenstein said of the suit. “That would be a major antitrust problem.”

    On Monday, two Democratic state senators promoted new legislation that would let California’s attorney general investigate gas price gouging during wartime.

    “This is not natural market forces at play,” said Senator Ben Allen, of El Segundo, a co-author of the bill. “That’s what we’re here to correct.”

    New evidence points to the retail market

    Even if the Iran war explains much of the statewide spike, it doesn’t explain why some California stations charge far more than nearby competitors. At a June 3 hearing, Tai Milder, head of the state’s petroleum watchdog, told senators the spike had exposed a separate problem.

    “This is a global supply shock, and so it’s affecting the whole country,” Milder told senators. “As prices go up, it’s revealing what we already know, which is we have a branded gasoline pricing problem.”

    His division’s data showed that the highest-price stations it examined were all major brands, not unbranded or hypermart stations, even though all gasoline sold in California meets the same fuel standards.

    Chevron also charged the highest premium over nearby competitors, the watchdog showed. Milder’s division has traced that gap to how the fuel is bought and sold.

    California has an unusually high share of sales through contracts in which a refiner sells fuel directly to a branded retailer at a price the refiner sets, the division’s analysis found. Those contracts can lock branded operators into paying more than unbranded operators for the same fuel.

    Jeremy Martin, director of fuels policy at the Union of Concerned Scientists, put it more simply: branded stations don’t get to shop around for the best price; they’re locked into buying from whichever refiner supplies their brand.

    Chevron spokesperson Ross Allen said the company’s branded stations “compete in a highly competitive marketplace where consumers have many choices” and that most are independently owned, setting their own prices based on local competition and costs. He blamed California’s energy policies, not Chevron’s pricing, for the state’s high gasoline prices.

    The Western States Petroleum Association, the state’s industry lobby, said California has fewer gas stations per capita than the rest of the country and fewer unbranded stations.

    “Can you name any consumer good where the branded version does not sell at a premium to a generic alternative?” WSPA spokesman Jim Stanley said. “That’s true whether you’re talking about cereal, snack foods, jeans, you name it.”

    The governor has made the wartime framing personal. Newsom singled out Chevron by name, accusing the company on social media of using its brand name to overcharge drivers amid wartime oil profits.

    The tools California did not use

    While California’s gasoline watchdog is finding weak points in the fuel market, the rest of the state’s price tools remain largely unfinished or unused.

    After price spikes, Newsom called two special legislative sessions in 2022 and 2024 and pushed through new powers meant to prevent future shocks. The laws created the state’s petroleum watchdog, which has since found an unexplained gasoline premium of about 41 cents per gallon between 2015 and 2024, costing California drivers an estimated $59 billion.

    But the laws also authorized more aggressive steps that have not taken effect: a possible penalty on excessive refinery margins, a requirement that refiners keep more gasoline in storage, and a rule requiring them to line up replacement fuel before shutting down for maintenance.

    A key reason: two refineries have shut down over the past year. This spring, average gas prices climbed above $6 a gallon as the Iran-Israel war roiled oil markets, and the administration has been working closely with refineries to ensure supply.

    The oil and gas sector, always a major lobbyist in California, spent $10.3 million lobbying Sacramento in the first three months of the year, according to California Secretary of State filings. The Western States Petroleum Association and Chevron made up the most of that spending total, respectively spending $4.3 million and $3.7 million.

    The most aggressive of the special session tools — the penalty — would have capped the gap between what refineries paid for crude oil and what they charged wholesalers for gasoline. In August 2025, a majority of Energy Commission members voted to shelve the idea for five years, saying they could not conclude that the benefits to consumers clearly outweighed the costs.

    That decision has drawn new criticism as refinery margins climb — from 49 cents per gallon in January to $1.24 per gallon in April, according to Energy Commission data cited by Consumer Watchdog. “The problem is we’ve sat on our hands and didn’t develop the tools — so they weren’t there when we needed them,” Consumer Watchdog President Jamie Court said. “That was a big mistake, and it cost consumers a lot of money.”

    The Newsom administration argues the unfinished tools wouldn’t have shielded consumers from this year’s spike. In written responses to CalMatters, Energy Commission spokesperson Niki Woodard said no state-level policy could protect against a global oil shock the size of the Iran war, and that California’s price increases this year have tracked national trends.

    The Energy Commission said it is actively advancing the resupply rule, but has not moved forward with the reserve requirement. Last year, Newsom pushed a major priority of the oil industry through the state Legislature: a measure aimed at boosting domestic oil production in Kern County.

    California mulls different gasoline strategies

    The spring spike has revived a more basic question: if California will still need gasoline for years, how does it keep a shrinking fuel system stable, competitive and affordable?

    One answer is more supply. The Newsom administration is tracking import infrastructure proposals for signs they could boost supply, including a proposed Phillips 66-Kinder Morgan project called the Western Gateway pipeline, which would move refined gasoline from central U.S. refineries into California and Arizona.

    Anthony Martinez, a spokesman for Newsom, called Western Gateway “a promising opportunity to bring additional gasoline supply into the state and bolster resilience.”

    Other proposals look at the structure of the retail market. A bill by Sen. Henry Stern, SB 1245, could give California more authority to change its unique gasoline blend, a cleaner-burning formula that is difficult to produce out of state, to make it easier to bring in fuel from elsewhere.

    Martin, of the Union of Concerned Scientists, said the blend made sense at its creation. He said its benefits are smaller now because federal fuel standards and cleaner cars have caught up, and its costs are higher because California has less refining capacity and depends more on imports.

    The Western States Petroleum Association opposes the idea, saying refiners already spent heavily to produce the cleaner fuel California required, and should not now be punished for making those investments.

    The bill, SB 493, authored by Allen and Senator Josh Becker of Menlo Park, would expand California’s price-gouging law by adding war to the list of emergencies that can trigger the state’s 10% cap on raising prices for gasoline and other essential goods, unless the increase is justified by higher costs.

    Becker and Stern have not taken any contributions from WSPA or Chevron, according to campaign filings compiled by CalMatters’ Digital Democracy database. Allen received a donation from Chevron in 2015, and none from WSPA, the database shows.

    The oil industry sees that as a return to an old fight. Zach Leary, a lobbyist with the Western States Petroleum Association, said California already debated price-gouging penalties during the 2023 special session, and that the Energy Commission decided the refinery-margin penalty could hurt supply, maintenance and consumers.

    Becker rejected that comparison, saying SB 493 targets a wartime emergency, not the regulation of refinery margins.

    But even Becker, who is proposing a new way to crack down on the industry, stopped short of calling for California to revisit the most powerful tool it has already set aside. Asked whether the Energy Commission should revisit its decision to delay the refinery-margin penalty, Becker called that “a separate process,” and “a separate decision,” one that is in the hands of the Newsom Administration.

  • Built by kids to learn native tongues

    Topline:

    Many Native American languages are endangered. With the help of his mentor, a 12-year-old in Michigan hopes to help preserve his language through robotics.

    Why it matters: U.S. Indian boarding schools played a major role in the loss of Indigenous languages. Children separated from their families were taught, sometimes violently, not to speak their native tongues, and many did not pass them on to their children.

    Today, some Native youth are learning their languages in schools. That's why SkoBot was invented.

    SAULT STE. MARIE, Mich. — The idea came to Danielle Boyer in a toy store. The inspiration? It was Tickle Me Elmo.

    "Whenever you'd press his belly, he would talk, and he would teach you things," she said. "There are toys that teach us in English, but there aren't toys that teach us Anishinaabemowin. And I wanted that to be different."

    Anishinaabemowin includes the Potawatomi, Odawa and Ojibwe languages. Exact estimates vary, but there are fewer than 10,000 people in the U.S. who speak Anishinaabemowin. That number is around 25,000 in Canada. Some Native languages have just a few dozen fluent speakers, while others have none.

    Boyer has seen how quickly language loss can happen. Her grandmother speaks Anishinaabemowin, but she is one of the last fluent speakers of their dialect.

    "It is devastating to feel like your language could be lost," said Boyer, a member of the Sault Ste. Marie Tribe of Chippewa Indians. "You lose your culture, you lose a way to describe who you are."

    U.S. Indian boarding schools played a major role in the loss of Indigenous languages. Children separated from their families were taught, sometimes violently, not to speak their native tongues, and many did not pass them on to their children.

    Today, some Native youth are learning their languages in schools. But Boyer said many of them still aren't invested. "They see it as another homework assignment."

    A woman in glasses talking to a tween in glasses in front of a laptop.
    Boyer and Hoy work on some last-minute adjustments to his AI-powered SkoBot before presenting at his school's end-of-year showcase, called the STEAM Museum.
    (
    Kadin Mills
    /
    NPR
    )

    That's why she invented the SkoBot. It's a customizable toy robot designed to get Indigenous children excited to learn their languages.

    "I can say 'Hey SkoBot, what is bear?' And it will say, 'Bear is makwa, makwa,' and it'll repeat it, right? So I can say, 'What is crane?' It'll say, 'Crane is ajijaak, ajijaak.'"

    SkoBots use a form of artificial intelligence to speak Indigenous languages, and they're small enough to mount on the user's shoulder. They sort of resemble mini R2-D2 droids, from Star Wars, except these robots are designed to look like woodland creatures and decorated in Native American florals.

    Through a nonprofit she started when she was 18, Boyer, now 25, has mentored hundreds of Native American children across the country, teaching them to build SkoBots of their own. One of them is 12-year-old Holden Hoy in Michigan's Upper Peninsula.

    "I was already a big fan of robotics and how they work, how you can bring inanimate objects to life," he said. "And I'm Ojibwe, and so I've always wanted to save the Ojibwe language."

    Hoy, a rising seventh-grader, showed off his design at an end-of-the-year science fair at his school, JKL Bahweting Anishinaabe School in Sault Ste. Marie. Like Boyer, he is a member of the Sault Tribe.

    He programmed his SkoBot to answer three questions ahead of his presentation. One of them was, "What's your name," to which the robot would respond in Hoy's voice: "Aaniin, Hello. Sabe indizhinikaaz, Bahweting indoonjibaa. I was built by Holden Hoy. I will not gain sentience and take over the world. Or will I?"

    Hoy named his SkoBot Sabe, which means Bigfoot in Anishinaabemowin. In Ojibwe culture, Bigfoot represents honesty, one of seven sacred teachings.

    His classmates and their parents stopped by his booth to see Sabe in action. Boyer was there too, helping Hoy with his presentation.

    "I'm very happy that people are actually coming to this booth," Hoy said. "I'm happy that they are learning things, and I'm really happy that I'm part of the Ojibwe."

    Sabe has one eye, a sensor that detects movement and lets it know to start listening.

    Close-up of three small robots on a table.
    Hoy's Sabe, or Bigfoot, SkoBot on display (right), alongside three other SkoBots that Boyer brought with her to show off at the STEAM Museum. Each represents a specific animal: a wolf, turtle and bear. Hoy's SkoBot is 3D printed in light gray, and its face is adorned with a footprint surrounded by floral designs.
    (
    Kadin Mills
    /
    NPR
    )

    "Basically, when it hears that one trigger word, it then plays a prerecorded audio file. So there isn't synthetic speech, there isn't any generative AI," said Boyer. "It's simply listening to what you're saying, identifying it and playing [audio files] that already exist."

    That means the SkoBots will never make things up, often called AI hallucinations. Hoy said it's important not to use generative AI. "AI tends to falsify things a lot, not get things from trustworthy sources."

    Boyer's goal isn't to replace interactions with real language speakers. Instead, it's to get kids interested in not only their languages, but in subjects like science, math and engineering as well. That includes getting them to think about how to use AI ethically.

    "Artificial intelligence, especially when it's not created by Indigenous people, stands to do a lot of harm to our communities," she said. "When you are putting accurate information into these models … you're giving away sacred information to companies that don't have our best interests at heart."

    And as chatbots have become more popular, Boyer said some people have turned to them to help them learn their languages. She's even seen large language models like ChatGPT invent fake words in Anishinaabemowin, which she said is dangerous. "If we're not learning our language correctly, we shouldn't learn it at all."

    Jocelyn Hoy is Holden's mom. She's excited that her son is not only exposed to their culture, but he's eager to know more. She said he's even been teaching her new things.

    "As someone who, at a time in my life, did not want to be identified as Native American … now as an adult, I cannot wait to learn more, and I think the SkoBots are going to help me and so many kids — so many people in general — learn their heritage and who they are."

    Holden Hoy said that heritage and the language are inseparable: "The language is the culture!"

    He added, "It is important to protect it, because it's some people's way of life. Generation after generation is based around this culture."

    Edited by: Steve Drummond and Lauren Migaki
    Visual design and development by: LA Johnson
    Copyright 2026 NPR

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  • Artist brings Korean public art tradition to Ktown
    A tall affordable-housing building with a mural covering its upper side wall. The mural depicts Korean drummers in traditional dress mid-performance beneath sweeping ribbons of color, with green mountains and faint architecture in the background and large pink plum blossoms across the lower portion. Green trees and a peaked rooftop are in the foreground under a clear blue sky.
    Artist Dave Young Kim's mural at the Korean Resource Center in Koreatown depicts traditional Korean drummers. The mural was informed by oral histories collected by youth in the Koreatown Storytelling Program.

    Topline:

    Korean American artist Dave Young Kim has completed his first mural in Koreatown, aiming to revive a tradition of Korean public art that has largely disappeared from the neighborhood where he grew up.


    The mural: Installed this summer at the Korean Resource Center, the mural centers on pungmulnori — a traditional Korean folk performance combining drumming, dance and acrobatics — with drummers moving beneath sweeping ribbons of color and plum blossoms blooming across the wall.

    Why it matters: Kim, 46, who was born and raised in Koreatown, says many of the culturally rooted murals he remembers from childhood have vanished, along with the public funding that once supported them. His work carries forward a tradition established by Korean American muralists like Dong-In Park in the late 1980s and early 1990s — at a time when longtime residents worry the neighborhood's Korean character is fading amid rapid change.

    This story first appeared on The LA Local.

    Murals depicting Korean drummers, dancers and historical figures were a large part of Dave Young Kim’s childhood in Koreatown.

    At the time, the Korean American artist didn’t know what all of the imagery meant, but it left a lasting impression on him.

    “We don’t learn culture via formal education. It’s all gleaned,” Kim said. “It’s just what we sense, and we feel a connection to it without actually knowing anything about it. It belongs to us, and it feels very familiar.”

    Many of the murals Kim remembers from his childhood have since disappeared. With his latest mural at the Korean Resource Center, Kim hopes to bring some of that visual imagery back to the neighborhood.

    Completed this summer, the mural is Kim’s first in Koreatown.

    The mural shows a group of traditional Korean drummers moving beneath sweeping ribbons of color, with plum blossoms blooming across the bottom of the wall. Faint outlines of traditional Korean architecture appear in the background.

    At the center of the mural is 풍물놀이 (pungmulnori), a traditional Korean folk performance that combines drumming, dance and acrobatics and has long been part of village festivals and celebrations.

    A close-up of the mural showing five Korean drummers in traditional white and black dress with yellow, blue and red sashes, playing hand drums and gongs. One younger drummer leaps mid-air in white sneakers. Faint outlines of traditional Korean architecture appear behind them, with pink plum blossoms blooming across the bottom.
    A close-up view of artist Dave Young Kim’s mural at the Korean Resource Center in Koreatown. The work depicts traditional Korean drummers.
    (
    Courtesy Dave Young Kim
    )

    For Kim, the project was a chance to reconnect the neighborhood with the kind of cultural imagery he says shaped his own understanding of identity growing up.

    “It was important to me growing up, and for me to see myself through very purposeful art, very intentional art,” he said. “For my own formation and identity, I think it was very important. I’d like to do that for future generations.”

    Kim, 46, who was born and raised in Koreatown, said the project felt different from his other murals because it was rooted in the community where he spent his childhood.

    “The formative years of my life are here,” he said.

    The project grew out of the Abbey Mural Prize, a national grant program that supports community-based public mural projects.

    As part of the project, Kim partnered with the Koreatown Storytelling Program, which trains youth to interview community elders. Students interviewed residents at Durae Crenshaw House, an affordable senior housing complex and home to the Korean Resource Center, and shared transcripts with Kim as he developed the mural.

    The architecture in the mural reflects the idea of home that emerged repeatedly in interviews with elders, Kim said.

    “There were a lot of iterations of the mockups. The very initial ones were very, very, very rooted in the stories, the narratives from the elders,” Kim said.

    The interviews also left an impression on Daisy Yeon, 17, one of the students who conducted them. She said participating in the project changed the way she thinks about Koreatown and its history.

    Yeon said she believes traditional Korean imagery still has a place in a neighborhood that has changed rapidly in recent years.

    “Personally, the way Koreatown has evolved in these few last years from the pandemic and the shift where people move into other Korean enclaves like Buena Park and Torrance, Koreatown is partly becoming a place of pop-up matcha spots, for example,” she said. “So I think it’s important for tradition to still be here.”

    Seeing the finished mural was “a full-circle moment,” she said, after spending months interviewing elders whose stories became part of the artwork.

    While researching Koreatown’s public art history, Kim learned many of the murals he saw as a kid grew out of cultural initiatives and public funding that no longer exist. He also discovered an earlier generation of Korean American muralists whose work once covered parts of Koreatown.

    In 1993, artist Dong-In Park completed a mural of traditional Korean farmers’ dance in the Korean Community Center at 981 S. Western Ave.

    He told the Los Angeles Times he hoped “the 1.5- and second-generation Korean kids” would not forget their language and history. Park, along with artists including Sonia Hahn and Kuk Chol Han, helped establish a tradition of public art celebrating Korean culture during the late 1980s and early 1990s.

    A large mural on the side of a building shows Korean drummers and dancers in white traditional dress with red and blue vests performing against a pale blue sky. A central figure leaps mid-dance holding a barrel drum, ribbons streaming from a hat. Korean text and "Korean Community Center" appear at the top right. Below, at street level, are a Mobil gas station, a traffic light and a billboard.
    An undated photo of Dong-In Park’s mural depicting a farmers band playing music and dancing to provide entertainment for Korea’s largely agricultural population. The mural was previously located at 981 Western Avenue in Koreatown.
    (
    Courtesy Mural Conservancy of Los Angeles
    )

    Kim wants his mural to carry that tradition forward while also reflecting the history of the community it was created for.

    The Korean Resource Center, founded by South Korean democracy activist Yoon Han-bong, has long organized around immigrant rights, workers’ rights and civic engagement. During the project, Kim learned that traditional Korean drumming has long played a role in the organization’s activism.

    In the mural, an older drummer who immigrated from Korea leads the group, followed by a middle-aged performer who learned from him and younger drummers wearing sneakers, modeled after college students who continue the tradition today.

    “Where we landed was very much to the core of what KRC is,” Kim said. “They are very activist and progressive.”

    The Koreatown of today is filled with Korean-owned businesses and Korean-language signs, Kim said, but far fewer public murals reflecting Korean culture.

    His latest mural isn’t about recreating the past so much as restoring something he believes has faded from the neighborhood.

    As an artist, Kim said, public art has the power to shape how people experience a place.

    “There’s something about the everyday landscape that you kind of are forced to take in,” he said, “and then as an artist, having the ability to shape what that might be.”

  • Company says "nearly half" of food waste removed
    A picture of the husk of the burned out Lineage Logisitics cold storage facility in Boyle Heights. Demolition equipment can be seen at the edges of the picture.
    Remediation work continues at Lineage Logistics, where residents and nearby businesses have had to deal with odor complaints as rotten food remains inside the ruined cold-storage Lineage Logistics warehouse in Boyle Heights nearly one month after the fire.

    Topline:

    Lineage, the company leasing the storage warehouse in Boyle Heights that burned in June, says “nearly half” the food waste has been removed.

    Why it matters: The rotting food inside the warehouse has led to noxious odors in the surrounding neighborhood, causing issues with vermin.

    The backstory: Lineage has been removing the food products for weeks and has faced citations and warnings from L.A. County and the South Coast Air Quality Management District.

    What's next: Demolition and cleanup of the rest of the burned building will be completed in the coming days, the company said, as it begins cleanup of the unburned section.

    Go deeper: Lineage cleanup by the numbers: Will they meet their deadline?

    Lineage Logistics, the company that operates the burned cold-storage warehouse in Boyle Heights, announced yesterday it's removed “nearly half” of the food waste there.

    The waste, the company said, has been sealed in deodorized containers and is being transported off-site.

    Lineage estimated that demolition and cleanup of the rest of the burned structure should be largely completed in the “coming days.”

    Before the weeklong fire that began on June 17, the warehouse stored approximately 44,000 tons, or 88 million pounds, of food.

    The company said it has started removing the wall separating the burned and unburned sections of the building this weekend to speed up the cleaning of the unburned structure.

    The process includes installing plastic sheeting where the wall used to be to help tamp down odors

    That part could take up to three days and may temporarily increase odors. To mitigate the smell, the company said three carbon filters will be added on the Union Pacific side of the warehouse.

    The company is trying to meet a 45-day deadline set by L.A. Mayor Karen Bass to complete the cleanup. Lineage has faced citations and warnings from L.A. County and the South Coast Air Quality Management District for "an ongoing odor nuisance" and “unsanitary and nuisance conditions.”

  • FDA panel supports widening access

    Topline:

    Advisers to the Food and Drug Administration voted in favor of easing regulation of popular peptides. The recommendations could pave the way for specialized pharmacies to produce them in the U.S.

    Why it matters: Currently, these peptides can't be made in the U.S., except for research purposes, leading many peptide users to buy unvetted substances sold online, with disclaimers such as "for research use only" and "not for human consumption."

    By narrow margins, the panel voted in favor of all but one. The FDA isn't required to follow advisory committee recommendations but typically does.

    A slate of popular peptide therapies has won the backing of a key advisory panel to the federal government — a step that could eventually open up broader access to the experimental drugs.

    In a marathon two-day meeting last week, the panel of doctors, academics and pharmacists recommended the Food and Drug Administration reclassify almost all of the compounds under consideration so that specialized pharmacies in the U.S. could begin offering them.

    Seven different peptide therapies — none of which are FDA-approved drugs — were under consideration.

    Currently, these peptides can't be made in the U.S., except for research purposes, leading many peptide users to buy unvetted substances sold online, with disclaimers such as "for research use only" and "not for human consumption."

    By narrow margins, the panel voted in favor of all but one. The FDA isn't required to follow advisory committee recommendations but typically does.

    The outcome represents a win for Health Secretary Robert F. Kennedy Jr., who has publicly supported peptide therapies, and the broader wellness and longevity industry, which stands to profit substantially.

    These peptides are promoted for a wide range of uses and are often taken together, including for injury recovery, muscle growth and fat loss, improving athletic performance, enhancing metabolism and more.

    If the agency takes the panel's recommendations, clinicians could have the ability to prescribe six peptide therapies: BPC-157, MOTS-c, KPV, TB-500, Epitalon and Semax.

    A compound called Emideltide, sometimes used for insomnia, was the only one to receive a down vote.

    The panel's endorsement of peptides was a striking rejection of the FDA's stance against them.

    While the level of evidence for each compound varies, all of them lack the kind of large, well-controlled trials in humans that are necessary to establish safety and effectiveness, which is required for drug approvals. Peptides are strings of amino acids — smaller than a protein — that often act as signaling molecules in our bodies and carry out many critical functions.

    They can be synthesized and delivered as drugs, often by injection. Some of those, like insulin, are naturally occurring in the body. Others are modified versions, as with the blockbuster GLP-1 obesity drugs.

    Scientists for the agency spoke extensively about the lack of reliable data for any of the seven peptides before the committee. They advised the panel to vote no.

    In some cases, they couldn't find any published clinical studies in humans — and there were safety concerns like the potential to encourage cancer growth or to trigger a massive immune response.

    A "foundational challenge" was simply defining the substances, because the chemical composition for peptides labeled with the same name varied considerably, explained FDA official Russell Wesdyk.

    "You will see many, many different forms," he said. "We can't create quality standards until we actually know what it is."

    The divide among the experts on the panel was a study in contrasts.

    Ahead of the meeting, eight new members were appointed. Most have ties to the peptide industry and include physicians who work for medical practices and companies that promote them.

    In almost all cases, they voted in favor of lifting restrictions.

    A spokesperson for the Department of Health and Human Services pushed back on criticism about potential conflicts of interest and said all underwent the standard ethics and vetting process.

    "I think it's about patient access," said Dr. Asare Christian, one of the panel members who runs a Pennsylvania-based clinic that advertises peptide protocols and hormone optimization.

    That sentiment was echoed throughout the many hours of public comment.

    Compounding pharmacies, large telehealth providers and others from the industry underscored the perils of the unregulated marketplace, with some offering anecdotes of patients obtaining unmarked vials from sketchy suppliers.

    "What we are advocating for is not the Wild West," said Brigham Buhler, who runs a telehealth company that offers hormone optimization and peptides and is an ally of Secretary Kennedy.

    "What we are advocating for is to slow down or shut down the gray and black market and to allow patients to have a safe and effective manufacturing process," he told the panel.

    But some panelists were skeptical of that argument.

    "I'm concerned that we are responding to market-induced demand rather than a decision based in solid science," Dr. Elizabeth Rebello, an anaesthesiologist at the University of Texas MD Anderson Cancer Center, commented after casting a no vote.

    The FDA committee was tasked with reviewing data that supports using these peptides to treat a variety of specific conditions, such as BPC-157 for treating ulcerative colitis, an inflammatory bowel disease.

    However, if the FDA ultimately reclassifies them and they are produced by compounding pharmacies in the U.S., clinicians would have discretion to write prescriptions outside of those narrow indications.

    During the meeting, industry groups — and some on the panel — repeatedly criticized the FDA presentations for not reflecting more recent scientific data on the substances, including results from other human studies that had been submitted ahead of time.

    FDA staff said they had considered everything submitted by the meeting deadline and would still take new information into account as they weigh next steps.

    The decision to place the products on the FDA's official list for compounding doesn't come close to the standards for drug approval, but some worry that nuance will not be clear to the public, which may not be aware of the limited data for humans.

    "I think this endorsement can be potentially harmful and I cannot in good conscience vote yes," said Dr. Brian Lee, a member of the panel and an associate professor at the Keck School of Medicine of USC.

    If the FDA moves to reclassify the peptides so that compounding pharmacies can make them, it will be through a formal rulemaking process that could stretch into next year or 2028. There is a possibility that Kennedy could invoke special authority to make them available sooner.

    The panel is scheduled to meet again in February to consider additional peptide therapies.
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