The Brief

During the COVID pandemic, J. Paul Grayson was hit with an avalanche of health problems — high blood pressure, prediabetes and a heart arrhythmia.

He also gained 40 pounds to his 6-feet 3-inches frame. "I felt like my weight was getting out of control," says the 73-year-old retiree, who lives on a ranch in Oklahoma. "I had to start taking all these medications that I never had to take before. I actually felt pretty depressed about my health."

About six months ago, Grayson began taking the popular weight-loss drug Ozempic. He knew the side effects could be rough, including nausea, constipation, and diarrhea. But he thought it would be worth it if he could stave off further heart problems by losing the extra weight.

"Right away, I started eating less and losing weight," he says. That was expected. But what Grayson hadn't expected was that the drug also immediately altered one of his other habits.

"I remember going to dinner for the first time [while taking Ozempic]," Grayson explains. "I ordered a beer, took a sip, and I couldn't finish it," he says. "You know how sometimes you taste a beer, and it's like, 'Oh my God, this tastes so good that I want to guzzle it.' Well, I didn't feel like guzzling. I just really felt like sipping it."
And, instead of having several beers with dinner, Grayson stopped at just one drink.

J. Paul Grayson experienced an interesting side effect when he started taking Ozempic: He lost his taste for alcohol.

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In the past year, prescriptions for both the diabetes drug Ozempic, and its weight-loss counterpart Wegovy, have skyrocketed, despite the fact that each costs about $1,000 a month, and some health insurers recently stopped covering them. Both drugs contain the same active ingredient, semaglutide, which belongs to a class of drugs known as GLP-1 (a.k.a. "glucagon-like peptide 1"). These drugs regulate your blood sugar and make you feel satisfied after eating. Ozempic is approved for treating diabetes and, in some cases, excess weight.

With the drug's surge in popularity, doctors and patients have begun to notice a striking side effect of these drugs: They appear to reduce people's cravings for alcohol, nicotine and opioids. They may also reduce some types of compulsive behaviors, such as gambling and online shopping.

"There's really been a large number of clinical and anecdotal reports coming in suggesting that people's drinking behaviors are changing and in some instances pretty substantially while taking [Ozempic or Wegovy]," says Christian Hendershot, a psychologist and addiction researcher at the University of North Carolina.

He's leading one of six clinical trials now underway aimed at understanding how semaglutide may alter people's drinking and smoking habits.

"All these reports, for the most part, are anecdotal," Hendershot adds. "At the same time, it does seem like there's a pretty strong signal here."

Scientists are hopeful that a new class of treatments for alcohol use disorder or smoking may be on the horizon. Some doctors have even started prescribing these drugs for this specific purpose, even though evidence from large, randomized controlled trials are still years away.

Stopping at just one cookie or beer

To many doctors and patients, like J. Paul Grayson, Ozempic's effect on alcohol came as a big surprise.

"Before Ozempic, I could consume a whole bottle of wine in an evening without trying real hard, along with a bag of chocolates," he says laughing. "But with Ozempic, even one beer didn't feel good to me somehow," he says.

"I had no idea this would happen," he adds. "Nobody told me anything about the drug affecting alcohol, too."

But for scientists who study GLP-1 drugs, this striking side effect was exactly what they expected. "It's really not surprising," says pharmacologist Elisabet Jerlhag.

For more than a decade now, Jerlhag and her colleagues at the University of Gothenburg in Sweden, have been figuring out in great detail how GLP-1 drugs, such as Ozempic, reduce alcohol consumption in rats.

She and other scientists have published nearly a dozen studies, showing how these drugs stop binge drinking in rats or mice, prevent relapse in "addicted" animals, and overall decrease their consumption of alcohol. "So we see a reduction by over 50%, which is quite dramatic," Jerlhag says.

Other studies in animals have also found that GLP-1 drugs reduce the consumption of nicotine, opioids, as well as psychostimulants, such as cocaine and methamphetamine.

So why would a weight-loss drug do this? Turns out, these drugs (as well as the GLP-1 hormone) don't just work on blood sugar. "They also work in your brain," says Dr. Lorenzo Leggio, who's the clinical director of the National Institute of Drug Abuse.

"The mechanism in the brain that regulates overeating overlaps with those responsible for the development and maintenance of addiction, including alcohol disorder," he says.

The role of dopamine

Studies in animals, as well as a few in people, offer tantalizing clues to how this mechanism works for both food and alcohol.

Imagine for a second taking a bite of a chewy, chocolate cookie. It's buttery and very sweet.

That first bite triggers the release of dopamine inside the part of your brain that controls your motivation, says neuroscientist Alexandra G. DiFeliceantonio, an assistant professor at Virginia Tech. "That dopamine essentially tells you, 'Hey, do that again!' Take another bite.' " And so, you want another bite. Maybe even another whole cookie. It's hard to stop.

Now imagine you're a beer lover and you take a big gulp of a cold IPA on a hot day. It also triggers a dopamine spike in the motivation center of the brain – just like the cookie.

"Dopamine in the striatum [the brain's motivation center] is the motivation and learning signal for everything. Not just for food," DiFeliceantonio says. "All addictive drugs increase dopamine there. That's a common thing."

And so after the first taste of beer, the dopamine tells you, "Do it again! Have another gulp."

But studies have found that in animals and people, GLP-1 drugs reduce the release of dopamine in this region when you eat something sweet and fatty, or when you consume alcohol. "The drug talks with our brain and says, 'we've had enough food here. So let's slow down. Let's have less appetite, let's have less food. Less alcohol," says NIDA's Leggio.

So you don't really feel like another bite of cookie, or as J. Paul Grayson said, "I didn't feel like guzzling. I just really felt like sipping it."

Oftentimes, now, he doesn't even feel like drinking at all. "When I still had wine or chocolate in the refrigerator, sometimes I would think, 'Oh, I should have some wine. I should have some chocolate.' But there just wasn't anything that made me get up and go to the refrigerator," he explains.

The 'horse has already left the barn'

Ozempic's potential to reduce alcohol consumption is now so well known that some people are seeking out the drug to help with their drinking, says Christian Hendershot.

"We're also hearing about clinicians prescribing for that reason," he says. "In many ways this is really kind of the indication that the horse has already left the barn. This is something that's already appearing to happen, whether we like it or not."

But NIDA's Leggio advises against this off-label use of Ozempic and Wegovy. "It's too early," he says. Ozempic may not work against alcohol for everyone, including people who don't have obesity.

So far, there has only been only one small randomized controlled study, looking at whether another GLP-1 drug could treat alcohol use disorder in people in general, as compared to cognitive behavioral therapy. This drug, called exenatide, isn't as potent as semaglutide (Ozempic) at inducing weight-loss or penetrating inside the brain. In the study, the drug reduced drinking in people with obesity, but it actually increased drinking in people who don't have obesity.

"We don't know why," Leggio says. One hypothesis is that the semaglutide caused people to lose weight even though they had normal weight and that led them to seek more calories through drinking, Leggio says.

"But that's only speculation," he adds. "We have to realize that no medication is going to work for everybody, and it's very important to identify the sub-class of patients for who this medication might work."

And he notes, in the end, maybe a newer version of the GLP-1 drugs might work better for treating addictions than diabetes.

Elisabet Jerlhag at the University of Gothenburg notes that people with obesity tend to have less severe side effects while taking semaglutide than people who don't have obesity. "With these drugs there's also a risk of developing pancreatitis," she says. "A person with alcohol use disorder may be at [elevated] risk for pancreatitis. So a doctor would need to monitor that."

On the other hand, if you have diabetes and you want to curb your alcohol intake then definitely talk to your doctor about the option of semaglutide, Leggio says. "Even more so if you have obesity and alcohol use disorder. Absolutely. Speak with your doctor."

'Many days I don't drink at all'

Meg Johnston's weight-loss medication has reduced her desire to drink. "Alcohol just doesn't sound as appetizing or appealing," she says.

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That's exactly what Meg Johnston, age 37, did about a month ago. During COVID, she also gained weight. "I make this joke that food was the only thing that brought me joy," she says. But she also drank much more. "I would drink out of boredom, just total boredom."

So she began taking semaglutide at the end of June. A part of her goal was to curb drinking. "I was hoping that I would be one of the people that the drug affected this way," says Johnston, who's a real estate agent in Washington, D.C.

And indeed, the drug has not disappointed her. "Many days I don't drink at all," she says. "It's hard to explain why. Alcohol just doesn't sound as appetizing or appealing. And now my tolerance is lower, too.

"This has been a welcome change for me," she adds. "During those first couple of weeks of taking the drug, I was very much focused on not vomiting and making sure I continue to have bowel movements. I just knew alcohol was going to make me feel terrible afterwards."

DUARTE, Calif. — Veteran actor T.K. Carter, who appeared in the horror film "The Thing" and "Punky Brewster" on television, has died at the age of 69.

Carter was declared dead Friday evening after deputies responded to a call regarding an unresponsive male in Duarte, California, according to the Los Angeles County Sheriff's Department.

Police did not disclose a cause of death or other details, but said no foul play was suspected.

Thomas Kent "T.K." Carter was born Dec. 18, 1956, in New York City and was raised in Southern California.

He began his career in stand-up comedy and with acting roles. Carter had been acting for years before a breakthrough role as Nauls the cook in John Carpenter's 1982 horror classic, "The Thing." He also had a recurring role in the 1980s sitcom "Punky Brewster."

Other big-screen roles include "Runaway Train" in 1985, "Ski Patrol" in 1990 and "Space Jam" in 1996.

"T.K. Carter was a consummate professional and a genuine soul whose talent transcended genres," his publicist, Tony Freeman, said in a statement. "He brought laughter, truth, and humanity to every role he touched. His legacy will continue to inspire generations of artists and fans alike."

Copyright 2026 NPR

Downtown Los Angeles

A person in an inflatable frog suit holds a sign during a protest in Los Angeles, California on January 10, 2026 against US Immigration and Customs Enforcement (ICE) after the fatal shooting of Renee Nicole Good in Minneapolis.

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A woman holds incense during a protest in Los Angeles, California on January 10, 2026 against US Immigration and Customs Enforcement (ICE) after the fatal shooting of Renee Nicole Good in Minneapolis.

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A person holds up a sign during a protest in Los Angeles, California on January 10, 2026 against US Immigration and Customs Enforcement (ICE) after the fatal shooting of Renee Nicole Good in Minneapolis. (Photo by ETIENNE LAURENT / AFP via Getty Images)

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A person holds up a sign during a protest in Los Angeles, California on January 10, 2026 against US Immigration and Customs Enforcement (ICE) after the fatal shooting of Renee Nicole Good in Minneapolis.

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Etienne Laurent

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A tourist bus drives past as people protest in front of the Metropolitan Detention Center (MDC), in Los Angeles, California on January 10, 2026 against US Immigration and Customs Enforcement (ICE) after the fatal shooting of Renee Nicole Good in Minneapolis.

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Pasadena

Alison Brett (far right) of La Crescenta at the Ice Out For Good protest in Pasadena on Jan. 10, 2026.

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Casey Law of South Pasadena at Ice Out For Good protest in Pasadena on Jan. 10.

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People have been taking to the streets nationwide this weekend to protest the Trump administration's immigration enforcement tactics following the death of Renee Good in Minneapolis, a 37-year-old woman who was shot and killed by a U.S. Immigration and Customs Enforcement (ICE) officer this week.

At least 1,000 events across the U.S. were planned for Saturday and Sunday, according to Indivisible, a progressive grassroots coalition of activists helping coordinate the movement it calls "ICE Out For Good Weekend of Action."

Leah Greenberg, a co-executive director of Indivisible, said people are coming together to "grieve, honor those we've lost, and demand accountability from a system that has operated with impunity for far too long."

"Renee Nicole Good was a wife, a mother of three, and a member of her community. She, and the dozens of other sons, daughters, friends, siblings, parents, and community members who have been killed by ICE, should be alive today," Greenberg said in a statement on Friday. "ICE's violence is not a statistic, it has names, families, and futures attached to it, and we refuse to look away or stay silent."

Large crowds of demonstrators carried signs and shouted "ICE out now!" as protests continued across Minneapolis on Saturday. One of those protestors, Cameron Kritikos, told NPR that he is worried that the presence of more ICE agents in the city could lead to more violence or another death.

"If more ICE officers are deployed to the streets, especially a place here where there's very clear public opposition to the terrorizing of our neighborhoods, I'm nervous that there's going to be more violence," the 31-year grocery store worker said. "I'm nervous that there are going to be more clashes with law enforcement officials, and at the end of the day I think that's not what anyone wants."

Demonstrators in Minneapolis on Saturday, Jan. 10, 2026.

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The night before, hundreds of city and state police officers responded to a "noise protest" in downtown Minneapolis. An estimated 1,000 people gathered Friday night, according to Minneapolis Police Chief Brian O'Hara, and 29 people were arrested.

People demonstrated outside of hotels where ICE agents were believed to be staying. They chanted, played drums and banged pots. O'Hara said that a group of people split from the main protest and began damaging hotel windows. One police officer was injured from a chunk of ice that was hurled at officers, he added.

Minneapolis Mayor Jacob Frey condemned the acts of violence but praised what he said was the "vast majority" of protesters who remained peaceful, during a morning news conference.

"To anyone who causes property damage or puts others in danger: you will be arrested. We are standing up to Donald Trump's chaos not with our own brand of chaos, but with care and unity," Frey wrote on social media.

Commenting on the protests, Department of Homeland Security (DHS) spokesperson Tricia McLaughlin told NPR in a statement, "the First Amendment protects speech and peaceful assembly — not rioting, assault and destruction," adding, "DHS is taking measures to uphold the rule of law and protect public safety and our officers."

Good was fatally shot the day after DHS launched a large-scale immigration enforcement operation in Minnesota set to deploy 2,000 immigration officers to the state.

In Philadelphia, police estimated about 500 demonstrators "were cooperative and peaceful" at a march that began Saturday morning at City Hall, Philadelphia Police Department spokesperson Tanya Little told NPR in a statement. And no arrests were made.

In Portland, Ore., demonstrators rallied and lined the streets outside of a hospital on Saturday afternoon, where immigration enforcement agents bring detainees who are injured during an arrest, reported Oregon Public Broadcasting.

A man and woman were shot and injured by U.S. Border Patrol agents on Thursday in the city. DHS said the shooting happened during a targeted vehicle stop and identified the driver as Luis David Nino-Moncada, and the passenger as Yorlenys Betzabeth Zambrano-Contreras, both from Venezuela. As was the case in their assertion about Good's fatal shooting, Homeland Security officials claimed the federal agent acted in self-defense after Nino-Moncada and Zambrano-Contreras "weaponized their vehicle."
Copyright 2026 NPR

Bob Weir, the guitarist and songwriter who was a founding member of the popular and massively influential American rock band the Grateful Dead, has died. According to a statement from his family posted on his website and social media pages, Weir died from underlying lung issues after recently beating cancer. He was 78.

A member of the Dead for its first three decades, and a keeper of the flame of the band's legacy for three more, Weir helped to write a new chapter of American popular music that influenced countless other musicians and brought together an enormous and loyal audience. The Grateful Dead's touring, bootlegging and merchandising set an example that helped initiate the jam-band scene. Its concerts created a community that brought together generations of followers.

Known to fans as "Bobby," he was born in San Francisco as Robert Hall Parber, but was given up for adoption and raised by Frederick and Eleanor Weir. In 1964, when he was still a teenager, Weir joined guitarist Jerry Garcia in a folk music band, Mother Mcree's Uptown Jug Band. In May of 1965 Weir and Garcia were joined by bassist Phil Lesh, keyboard player Ron "Pigpen" McKernan and drummer Bill Kreutzmann to form an electric, blues-based rock and roll band that was briefly named The Warlocks. After discovering that there was another band using that name, Jerry Garcia found a phrase that caught his eye in a dictionary and in December of that year they became the Grateful Dead, launching a 30-year run over which time they grew into a cultural institution.

Weir was a singular rhythm guitarist who rarely played solos, choosing instead to create his own particular style of chording and strumming that gracefully supported Garcia's distinctive guitar explorations especially during the extended jams which were the heart of the band's popularity.

Lyrics were largely a product of a communal effort between Weir and Garcia, as well as lyricists John Perry Barlow, Robert Hunter, that often blurred the lines between who wrote what. The opening lines to "Cassidy," which first appeared on Weir's 1972 solo album Ace and was played by the Dead on live recordings including the 1981 double album Reckoning, reflect the combination of metaphor, rhyme and storytelling set to memorable melodies that the band's audiences could memorize, analyze and sing along to:

I have seen where the wolf has slept by the silver stream
I can tell by the mark he left you were in his dream
Ah, child of countless trees
Ah, child of boundless seas
What you are, what you're meant to be
Speaks his name, though you were born to me
Born to me, Cassidy

Weir's emotive singing, on "Cassidy" and other songs like "Sugar Magnolia," "One More Saturday Night" and the band's unofficial theme, "Truckin', " often included whoops and yells, in contrast to Garcia's calm and steady approach. His occasional tendency to forget lyrics was usually greeted by thunderous applause from fans.

After Garcia's death in 1995, at age 53, the surviving members of the band carried on in various forms and arrangements, the longest running of which was Weir's Dead & Company, which also featured Grateful Dead drummers Kreutzmann and Mickey Hart. Weir and the band concluded their "final tour" in July of 2023, but then returned to the stage for two extended residencies at the Sphere in Las Vegas, in 2024 and 2025.

A self-described "compulsive music maker," in 2018 Weir formed yet another band to mine the depths of the Grateful Dead catalog. It was a stripped-down guitar, acoustic bass and drums outfit that he called Bobby Weir & Wolf Bros. Its members included renowned bassist and producer Don Was.In October of 2022, Weir & Wolf Bros worked with a classical music arranger to present yet another iteration of the Dead's catalog, notable for never being played the same way twice, with a group that largely only plays what's written on the paper in front of them, the 80-piece National Symphony Orchestra.

In a 2022 interview with NPR, Weir explained the reason for that collaboration, and in doing so, seemed to offer a possible explanation for why the band's music stayed so popular for so long: "These songs are … living critters and they're visitors from another world — another dimension or whatever you want to call it — that come through the artists to visit this world, have a look around, tell their stories. I don't know exactly how that works, but I do know that it's real."

After Jerry Garcia's death in 1995, Weir kept the legacy of the Grateful Dead alive, touring with bands that came to include generations of musicians influenced by the group. Here, Weir performs with The Dead at Madison Square Garden in New York City in 2009.

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Weir's work to shepherd and sustain the Dead's legacy was rewarded by ever younger generations of Deadheads, the band's loyal following, who attended tour after tour, often following the band from city to city as their parents and grandparents did during in the 1960's, '70s, '80s and '90s.

In an interview with Rolling Stone in March 2025, Weir shared his thoughts on his legacy, as well as on death and dying, that had a hint of the Eastern philosophies that were popular when the Grateful Dead emerged from the peace and love hippie movement of San Francisco. "I'll say this: I look forward to dying. I tend to think of death as a reward for a life well-lived," he said.

Copyright 2026 NPR