The Brief

During the COVID pandemic, J. Paul Grayson was hit with an avalanche of health problems — high blood pressure, prediabetes and a heart arrhythmia.

He also gained 40 pounds to his 6-feet 3-inches frame. "I felt like my weight was getting out of control," says the 73-year-old retiree, who lives on a ranch in Oklahoma. "I had to start taking all these medications that I never had to take before. I actually felt pretty depressed about my health."

About six months ago, Grayson began taking the popular weight-loss drug Ozempic. He knew the side effects could be rough, including nausea, constipation, and diarrhea. But he thought it would be worth it if he could stave off further heart problems by losing the extra weight.

"Right away, I started eating less and losing weight," he says. That was expected. But what Grayson hadn't expected was that the drug also immediately altered one of his other habits.

"I remember going to dinner for the first time [while taking Ozempic]," Grayson explains. "I ordered a beer, took a sip, and I couldn't finish it," he says. "You know how sometimes you taste a beer, and it's like, 'Oh my God, this tastes so good that I want to guzzle it.' Well, I didn't feel like guzzling. I just really felt like sipping it."
And, instead of having several beers with dinner, Grayson stopped at just one drink.

J. Paul Grayson experienced an interesting side effect when he started taking Ozempic: He lost his taste for alcohol.

(

J. Paul Grayson

)

In the past year, prescriptions for both the diabetes drug Ozempic, and its weight-loss counterpart Wegovy, have skyrocketed, despite the fact that each costs about $1,000 a month, and some health insurers recently stopped covering them. Both drugs contain the same active ingredient, semaglutide, which belongs to a class of drugs known as GLP-1 (a.k.a. "glucagon-like peptide 1"). These drugs regulate your blood sugar and make you feel satisfied after eating. Ozempic is approved for treating diabetes and, in some cases, excess weight.

With the drug's surge in popularity, doctors and patients have begun to notice a striking side effect of these drugs: They appear to reduce people's cravings for alcohol, nicotine and opioids. They may also reduce some types of compulsive behaviors, such as gambling and online shopping.

"There's really been a large number of clinical and anecdotal reports coming in suggesting that people's drinking behaviors are changing and in some instances pretty substantially while taking [Ozempic or Wegovy]," says Christian Hendershot, a psychologist and addiction researcher at the University of North Carolina.

He's leading one of six clinical trials now underway aimed at understanding how semaglutide may alter people's drinking and smoking habits.

"All these reports, for the most part, are anecdotal," Hendershot adds. "At the same time, it does seem like there's a pretty strong signal here."

Scientists are hopeful that a new class of treatments for alcohol use disorder or smoking may be on the horizon. Some doctors have even started prescribing these drugs for this specific purpose, even though evidence from large, randomized controlled trials are still years away.

Stopping at just one cookie or beer

To many doctors and patients, like J. Paul Grayson, Ozempic's effect on alcohol came as a big surprise.

"Before Ozempic, I could consume a whole bottle of wine in an evening without trying real hard, along with a bag of chocolates," he says laughing. "But with Ozempic, even one beer didn't feel good to me somehow," he says.

"I had no idea this would happen," he adds. "Nobody told me anything about the drug affecting alcohol, too."

But for scientists who study GLP-1 drugs, this striking side effect was exactly what they expected. "It's really not surprising," says pharmacologist Elisabet Jerlhag.

For more than a decade now, Jerlhag and her colleagues at the University of Gothenburg in Sweden, have been figuring out in great detail how GLP-1 drugs, such as Ozempic, reduce alcohol consumption in rats.

She and other scientists have published nearly a dozen studies, showing how these drugs stop binge drinking in rats or mice, prevent relapse in "addicted" animals, and overall decrease their consumption of alcohol. "So we see a reduction by over 50%, which is quite dramatic," Jerlhag says.

Other studies in animals have also found that GLP-1 drugs reduce the consumption of nicotine, opioids, as well as psychostimulants, such as cocaine and methamphetamine.

So why would a weight-loss drug do this? Turns out, these drugs (as well as the GLP-1 hormone) don't just work on blood sugar. "They also work in your brain," says Dr. Lorenzo Leggio, who's the clinical director of the National Institute of Drug Abuse.

"The mechanism in the brain that regulates overeating overlaps with those responsible for the development and maintenance of addiction, including alcohol disorder," he says.

The role of dopamine

Studies in animals, as well as a few in people, offer tantalizing clues to how this mechanism works for both food and alcohol.

Imagine for a second taking a bite of a chewy, chocolate cookie. It's buttery and very sweet.

That first bite triggers the release of dopamine inside the part of your brain that controls your motivation, says neuroscientist Alexandra G. DiFeliceantonio, an assistant professor at Virginia Tech. "That dopamine essentially tells you, 'Hey, do that again!' Take another bite.' " And so, you want another bite. Maybe even another whole cookie. It's hard to stop.

Now imagine you're a beer lover and you take a big gulp of a cold IPA on a hot day. It also triggers a dopamine spike in the motivation center of the brain – just like the cookie.

"Dopamine in the striatum [the brain's motivation center] is the motivation and learning signal for everything. Not just for food," DiFeliceantonio says. "All addictive drugs increase dopamine there. That's a common thing."

And so after the first taste of beer, the dopamine tells you, "Do it again! Have another gulp."

But studies have found that in animals and people, GLP-1 drugs reduce the release of dopamine in this region when you eat something sweet and fatty, or when you consume alcohol. "The drug talks with our brain and says, 'we've had enough food here. So let's slow down. Let's have less appetite, let's have less food. Less alcohol," says NIDA's Leggio.

So you don't really feel like another bite of cookie, or as J. Paul Grayson said, "I didn't feel like guzzling. I just really felt like sipping it."

Oftentimes, now, he doesn't even feel like drinking at all. "When I still had wine or chocolate in the refrigerator, sometimes I would think, 'Oh, I should have some wine. I should have some chocolate.' But there just wasn't anything that made me get up and go to the refrigerator," he explains.

The 'horse has already left the barn'

Ozempic's potential to reduce alcohol consumption is now so well known that some people are seeking out the drug to help with their drinking, says Christian Hendershot.

"We're also hearing about clinicians prescribing for that reason," he says. "In many ways this is really kind of the indication that the horse has already left the barn. This is something that's already appearing to happen, whether we like it or not."

But NIDA's Leggio advises against this off-label use of Ozempic and Wegovy. "It's too early," he says. Ozempic may not work against alcohol for everyone, including people who don't have obesity.

So far, there has only been only one small randomized controlled study, looking at whether another GLP-1 drug could treat alcohol use disorder in people in general, as compared to cognitive behavioral therapy. This drug, called exenatide, isn't as potent as semaglutide (Ozempic) at inducing weight-loss or penetrating inside the brain. In the study, the drug reduced drinking in people with obesity, but it actually increased drinking in people who don't have obesity.

"We don't know why," Leggio says. One hypothesis is that the semaglutide caused people to lose weight even though they had normal weight and that led them to seek more calories through drinking, Leggio says.

"But that's only speculation," he adds. "We have to realize that no medication is going to work for everybody, and it's very important to identify the sub-class of patients for who this medication might work."

And he notes, in the end, maybe a newer version of the GLP-1 drugs might work better for treating addictions than diabetes.

Elisabet Jerlhag at the University of Gothenburg notes that people with obesity tend to have less severe side effects while taking semaglutide than people who don't have obesity. "With these drugs there's also a risk of developing pancreatitis," she says. "A person with alcohol use disorder may be at [elevated] risk for pancreatitis. So a doctor would need to monitor that."

On the other hand, if you have diabetes and you want to curb your alcohol intake then definitely talk to your doctor about the option of semaglutide, Leggio says. "Even more so if you have obesity and alcohol use disorder. Absolutely. Speak with your doctor."

'Many days I don't drink at all'

Meg Johnston's weight-loss medication has reduced her desire to drink. "Alcohol just doesn't sound as appetizing or appealing," she says.

(

Nicole Jackson

/

Meg Johnston

)

That's exactly what Meg Johnston, age 37, did about a month ago. During COVID, she also gained weight. "I make this joke that food was the only thing that brought me joy," she says. But she also drank much more. "I would drink out of boredom, just total boredom."

So she began taking semaglutide at the end of June. A part of her goal was to curb drinking. "I was hoping that I would be one of the people that the drug affected this way," says Johnston, who's a real estate agent in Washington, D.C.

And indeed, the drug has not disappointed her. "Many days I don't drink at all," she says. "It's hard to explain why. Alcohol just doesn't sound as appetizing or appealing. And now my tolerance is lower, too.

"This has been a welcome change for me," she adds. "During those first couple of weeks of taking the drug, I was very much focused on not vomiting and making sure I continue to have bowel movements. I just knew alcohol was going to make me feel terrible afterwards."

An appeals court issued a ruling Friday that strikes down a federal government effort to block a lower court’s order requiring the construction of 2,550 new housing units on the Veterans Affairs campus in West Los Angeles.

The long-running case, brought forward by disabled veterans struggling with homelessness in the L.A. area, has centered on the use of the sprawling 400-acre VA campus.

U.S. District Judge David O. Carter had previously scrutinized leases for the private Brentwood School’s athletic facilities, a parking lot company, an oil drilling enterprise and UCLA’s baseball stadium.

Ruling that the campus was meant to aid veterans, Carter ordered the VA to not renew the leases and quickly build 750 units of temporary housing and 1,800 units of permanent housing.

But Carter’s September 2024 order has been on hold ever since the defendants asked the 9th Circuit Court of Appeals to review his decision.

Case returns to lower court

On Friday, more than two-thirds of the court’s 29 judges ruled against the VA’s petition for a rehearing.

“It's a historic day for veterans,” said Mark Rosenbaum, an attorney with Public Counsel representing the plaintiffs.

“The government has been fighting their veterans, who went to fight on behalf of the nation,” he added. “They've been fighting them like they are the enemy. They went to the district court to fight. They lost.”

Rosenbaum said he’s pleased to see the case return to Carter’s courtroom after a long appeals process. Carter, himself a Marine Corps veteran who served in the Vietnam War, took an active role in pushing the VA to address a homelessness crisis that has thousands of former service members experiencing homelessness on any given night in L.A. County.

Could the VA pursue further appeals? 

Carter has also ordered the VA to stop using veterans' disability payment benefits as a reason to make them ineligible for supportive housing programs due to income restrictions.

But Rob Reynolds, an Iraq War veteran who advocates for L.A.’s veteran community, said the federal government’s attempts to win an appeal could continue.

“The government can still appeal this to the U.S. Supreme Court,” Reynolds said.

When veterans involved in the case first heard today’s news on the 9th Circuit ruling, he said they immediately asked about the potential for further appeals.

“All of us are really hoping that the government stops this fight, and that we can get housing built for our veterans and end this madness once and for all,” Reynolds said.

A spokesperson for the VA declined to comment on the ruling, saying the department does not discuss pending litigation.

Jenny Yang, a comedian from L.A., has been traveling across the country turning immigrant grocery stores into comedy hubs. Now she’s back in L.A. getting ready to start a mini-residency in Highland Park, tape her first one-hour special and share moments from the tour.

Yang kicked off her Good Egg Immigrant Grocery Store Standup Comedy Tour in June in L.A., then took it to 15 cities across the country. She told LAist the decision came as a way to cope with the grief from her dad’s death, 10 failed in vitro fertilization treatments between 2020 and 2025 and seeing the news of Immigration and Customs Enforcement raids spread across the country.

She said the idea to tour grocery stores was a way to reclaim those spaces, after immigration enforcement left many afraid to go out and do simple tasks like buying groceries.

“If we cannot laugh in front of a wall of instant ramen around our bok choy," Yang said, "then what is the American dream for?"

Her routine wove in stories about her fertility struggles and the challenges of having to be a “good egg” growing up as the child of immigrant parents from Taiwan. Her hope for the tour was to connect with people, to make jokes and help people feel lighter after.

The tour proceeds went to local nonprofits serving immigrant communities, and Yang said those organizations helped recruit the grocery stores. She said some stores said no at first — they felt overwhelmed by ICE activity in their city, had lost staff or worried about drawing attention.

“That's part of the story of the tour is it's one thing to want to imagine this beautiful world where you can tell jokes inside of immigrant grocery stores," Yang said. "It's another thing to know what those obstacles are, and I think that's still very telling for where we are as a country.”

One moment stood out to Yang: performing at Shuang Hur Supermarket in Minneapolis. It’s near the memorial for Alex Pretti, the nurse that a U.S. Border Patrol agent shot and killed in January as federal agents carried out immigration enforcement in the city.

“I was able to talk to Henry, the owner who’s a Chinese American uncle. [He] was so proud of being able to help his regular patrons, who for the most part even though it was an Asian centered grocery store, were majority Latino,” Yang said. “I was able to bear witness to their resilience as a community, what they did to take care of each other.”

Now she’s back in L.A. and is doing a mini-residency at the Outside In Theater at 5317 York Blvd. in Highland Park. Her first show is 6 p.m., Saturday, Sept. 12, followed by shows on Sept. 19 and 26 at the same time. Tickets are pay-what-you-can, and you can find them at Outside In's website.

In February 2027, Yang will be taping her first one-hour special at Rancho Meat Market #1 in Lincoln Heights. She describes it as a love letter to Los Angeles that’s endured so much, from the ICE raids to the January fires.

You can follow Jenny Yang’s work here.

When you wanna keep it simple for lunch — go with a sandwich.

Take N’ Taste — a sandwich business based in Burbank — offers a variety of options, including classics like melts and dips, and delivers to locals from a home kitchen.

What goes into running a MEHKO business?

A Microenterprise Home Kitchen Operation (MEHKO) is a type of permit available through the L.A. County Department of Public Health, which allows folks to run a food service business from their home. Although it has more limitations than a brick-and-mortar restaurant, it also provides an avenue to build small business.

According to the L.A. County Department of Public Health's website, it allows MEHKO businesses to sell up to 30 meals per day with a limit of 90 meals per week. For businesses that are approved for the county's compact mobile food operations permit, that number jumps up to 80 meals per day and 200 meals per week.

The permit doesn't allow third-party food delivery app use, meaning they deliver directly to you or you schedule a pickup with the business.

About the owners

Ashley Childs' local culinary background runs pretty deep — she's worked at places like Tony’s Darts Away, a gastropub in Burbank, as well as the vegan hole-in-the-wall restaurant Doomie's Home Cookin' on Melrose. As the chef-and-owner of Take N' Taste, she's carried those experiences into her current work, which serves as a side hustle while she pursues a master's degree in nutritional science.

It's also a side hustle of sorts for co-owner James Schroeder, who works primarily as a storyboard artist. He previously worked managing the East Hollywood Farmers Market, which helped him connect with local farmers and learn the best ways to source ingredients.

Restaurant details

• Since Childs was previously vegan, she developed vegan alternatives for many of the menu items.

Menu items we tried

Take N' Taste smoked BBQ chicken sandwich.

(

Courtesy Ashley Childs

)

• Roast Beef Dip (roast beef, Swiss cheese, grilled onions and horseradish garlic mayo on a rustic French baguette)
• Smoked BBQ Jackfruit Sandwich (organic smoked barbecue jackfruit on a ciabatta roll with jalapeño slaw and homemade dill pickles)
• Blackened Chicken Sandwich (organic blackened chicken, jalapeño slaw and garlic mayo on a Japanese milk bun)

What should we try next?

In 2017, only about 400 public schools in the state offered bilingual education.

But in the 10 years since voters approved Prop 58 overturning the ban on bilingual teaching, that number has now grown to more than 1,000.

It's still not enough to meet the demand from parents and caregivers who want their kids to have the advantages of bilingualism, as well as academic support for Spanish and other languages spoken at home.

California officials now want to increase the number of public schools to 1,600 by 2030.

“These programs have expanded quickly, but these schools continue to really struggle to find and retain the teachers to teach in them,” said Cati de los Rios, an associate professor of language, literacy, and culture at UC Berkeley.

She said the lag in the teacher pipeline is the main problem. The bilingual education ban, approved by voters in 1998 through Prop. 227, also shriveled up university training programs for bilingual teachers.

There are signs of recovery. The number of teachers trained in bilingual education in California has grown to a record of nearly 1,400 in the 2023-2024 school year.

Educators feel the momentum is growing. On Saturday, some of them are set to gather at California State University, Dominguez Hills for a yearly Bilingual Teacher Conference to take advantage of that energy.

“It's a celebration … to highlight the importance and the beauty of being bilingual and supporting our students and our families and our communities to really embrace bilingualism,” said Elexia Reyes-McGovern, a professor of teacher education at the campus.

The keynote speaker, she said, will talk about how teachers can nurture students’ thinking about mathematics in English and a second language.

Other languages

A report out this year signaled that the vast majority of the bilingual education teacher graduates received training to teach Spanish and English, but the number of graduates across the state authorized to teach other languages, such as Mandarin, Vietnamese and Armenian also grew.

Leslie Cortes Sanchez, a 2023 - 2024 bilingual education teacher trainee in UC Berkeley’s Teacher Education program, in a California classroom.

(

Manny Herrera

/

Courtesy Cati de los Rios

)

“[I taught] two sisters and they were twins, and they came from Guatemala,” said Cristal Guadarrama, who teaches fifth grade Spanish-English dual language in South L.A.

She crafted a lesson one day, she says, around those students’ indigenous language, in particular the word for table, which was similar to the Spanish word.

“That was showing the other kids, like, ‘oh wow, there's so many similarities within the language. It's just like a change of letters.’ So then they started wanting to learn,” she said.

Research shows students in bilingual programs attend school more regularly and help recent immigrants enter all-English classes faster than without bilingual support.

California’s been engaged in a policy back and forth with bilingualism and multilingualism for over 150 years. For now, the anniversary of Prop. 58’s approval suggests a future that’s more embracing of non-English languages as an asset to learning, rather than a liability.

“We've changed the mindset of this kind of linguistic supremacy of English-only monolingualism being the present and the future,” de los Rios said.