Sponsored message
Logged in as
Audience-funded nonprofit news
radio tower icon laist logo
Next Up:
0:00
0:00
Subscribe
  • Listen Now Playing Listen
  • Listen Now Playing Listen

The Brief

The most important stories for you to know today
  • Damage from gut bacteria may play a role

    Topline:

    It's unclear why colon cancer cases have doubled in people under 55 over the past two decades, a staggering rise that has alarmed doctors and cancer researchers. But part of the story could be colibactin, a toxin made by certain strains of E. coli and other bacteria.

    Why now: In a study out this week, researchers have identified a strong link between this DNA-damaging toxin and colon cancer among younger patients. The team, based at UC San Diego, analyzed tissue samples from close to 1,000 colorectal cancer patients across four continents. They found the majority had cancers bearing mutations that signaled a past encounter with colibactin.

    What triggers a DNA-damaging toxin: The study is a new clue into the rise in colorectal cancer in the young. Scientists believe some confluence of environmental factors, including diet, a sedentary lifestyle, medication and so on, is driving this steep rise.

    Read on ... for to learn what else may be driving this rise in cancer cases.

    It's unclear why colon cancer cases have doubled in people under 55 over the past two decades, a staggering rise that has alarmed doctors and cancer researchers.

    But part of the story could be colibactin, a toxin made by certain strains of E. coli and other bacteria. In a study out this week, researchers have identified a strong link between this DNA-damaging toxin and colon cancer among younger patients.

    The team, based at UC San Diego, analyzed tissue samples from close to 1,000 colorectal cancer patients across four continents. They found the majority had cancers bearing mutations that signaled a past encounter with colibactin.

    "You can think of it as the weapon system of a bacteria to fight other bacteria and to defend themselves," says Ludmil Alexandrov, the lead author of the study, which was published in Nature this week.

    Strikingly, those under the age of 40 with early-onset colon cancer were three to five times more likely to have these mutations than those in their 70s and older.

    The thinking goes that in some people, this bacterial weaponry — technically called a "genotoxin" — can get directed at their gut cells, seeding mutations that put them at increased risk of developing colorectal cancer.

    According to their data, this exposure isn't ongoing when the cancer is diagnosed. Instead, it appears to have happened during childhood.

    "Our estimate is that it happens within the first 10 years of life," Alexandrov says. "So if you get that mutation at age 5, that puts you 20 to 30 years ahead of schedule for getting colorectal cancer."

    While the study shows a strong association, the data can't prove colibactin caused these patients to develop cancer at a younger age. And researchers in the field don't expect E. coli, or any single microbe for that matter, to be the skeleton key for the surge in colorectal cancer.

    "That would be too simple," says Christian Jobin, a microbiome researcher at the University of Florida.

    More likely, he says, colibactin — studied closely in E. coli but produced by other bacteria too is one "hit" among many to our microbiome, which together may place some people on a faster trajectory for developing cancer.

    What triggers a DNA-damaging toxin

    The study is a new clue into the rise in colorectal cancer in the young. Scientists believe some confluence of environmental factors, including diet, a sedentary lifestyle, medication and so on, is driving this steep rise.

    These could be having downstream effects on the microbes in our gut like E. coli.

    "It's been really perplexing," says Dr. Neelendu Dey, a gastroenterologist whose lab focuses on the gut microbiome at the Fred Hutchinson Cancer Center. "The microbes that may contribute to cancer risk are tricky to understand."

    The family of microbes to which E. coli belongs is actually the most prevalent type of bacteria in your gut during the very early stages of life.

    About 20% to 30% of people have strains of E. coli that can synthesize this toxin, but that doesn't mean it's necessarily having "deleterious effects," says Jobin, whose lab has pioneered related research.

    In other words, it's not some new infectious agent that simply needs to be eliminated.

    Adding to the puzzle: Not everyone with colorectal cancer has these signatures of colibactin-related mutations.

    There's something provoking the bacteria to behave this way, perhaps giving it an advantage to grow in more abundance. "What triggers this weapon or the deployment?" Jobin says. "We don't know but we have to consider the environment."

    "We know that some of these E. coli that produce colibactin are influenced by diet, inflammation and medication," he adds.

    Jobin says the new research is "fantastic" because it bridges early preclinical research in animals with "real life humans," and opens new avenues for research.

    Studies conducted on animals have shown colibactin exposure can drive cancer development.

    For example, deleting the genetic region responsible for producing this toxin in E. coli can actually incapacitate the bacteria from promoting cancer in animals. Feeding them more or less fiber can affect tumor growth. And stopping inflammation can also fend off cancer in these lab studies of colibactin.

    Antibiotics use and nutrition, could be at play

    Because they sequenced the genome of cancer from patients all over the globe, Alexandrov says the researchers could tell these mutations related to colibactin are actually quite rare in more "rural, non-industrialized" regions of Africa and Asia, whereas they turn up more frequently in the U.S. and Western Europe.

    That evidence, coupled with the findings that it's a result of early childhood exposure, gives them a handful of hypotheses about what could be at play.

    He says some of their top suspects are the mode of birth (cesarean section vs. vaginal delivery), breastfeeding, the use of antibiotics and nutrition, for example whether children were fed ultra processed foods.

    "All of these factors are known to substantially affect the microbiome and there is some evidence they may impact this [colibactin producing] bacteria, but we really need to investigate each one carefully."

    Dey views all of these as plausible, particularly antibiotics, given that other research teams have linked early-life antibiotic use to increased risk of colorectal cancer later on.

    More broadly, he says he hopes researchers can eventually find microbes that serve as "biomarkers" for identifying people at risk of developing pre-cancers. And, perhaps down the line, drugs can be designed to target toxins like colibactin to counter their harmful effects.

    "Of course, it sounds simple, but we have to acknowledge the ecological lessons learned in other contexts," he says. "When you try to take out, or introduce a species, it can have effects that you didn't anticipate, so this all needs to be done very thoughtfully."

    Copyright 2025 NPR

  • Supreme Court seems inclined to rule against Trump

    Topline:

    A majority of the Supreme Court justices seemed skeptical of the Trump administration's argument on birthright citizenship yesterday and appeared ready to rule in favor of upholding automatic citizenship for babies born on U.S. soil.

    Keep reading... for details on the questions posed to lawyers, including conservative justices tough questions for President Donald Trump's solicitor general, D. John Sauer.

    A majority of the Supreme Court justices seemed skeptical of the Trump administration's argument on birthright citizenship Wednesday and appeared ready to rule in favor of upholding automatic citizenship for babies born on U.S. soil.

    That included multiple conservative justices, who had tough questions for Trump's solicitor general, D. John Sauer. Sauer argued the government's case against birthright citizenship, the practice enshrined in the 14th Amendment in the Constitution, which became law in 1868.

    It states: "All persons born or naturalized in the United States, and subject to the jurisdiction thereof, are citizens of the United States and of the State wherein they reside."

    Sauer, however, asserted that contrary to the law as understood for 160 years, the 14th Amendment does not confer automatic citizenship on every baby born in the U.S. He told the court that the true meaning of the amendment was to grant citizenship to former slaves and their children, no more. And, therefore, President Trump was well within his rights when he signed an executive order barring citizenship for children born in this country to parents who are illegally here, or who are here legally, but on long-term visas.

    But Chief Justice John Roberts was doubtful about that executive order.

    "The examples you give to support that strike me as very quirky," Roberts told Sauer. "And then you expand it to a whole class of illegal aliens," he continued. "I'm not quite sure how you can get to that big group from such tiny and, sort of, idiosyncratic examples."

    "We're in a new world now," Sauer contended. "A billion people are one plane ride away from having a child who's a U.S. citizen."

    "It's a new world," Roberts replied, but "it's the same Constitution."

    Not seeing a play button? Click here.


    Justice Neil Gorsuch noted that the Trump executive order focuses on parents, but the 14th Amendment focuses on birthright for the child. He asked: how would you know who the father is, or the mother? What if they're unmarried? Whose house do they live in?

    Justice Amy Coney Barrett questioned the practicality of the Trump proposal.

    "How would it work?" she asked. "How would you adjudicate these cases? You're not going to know at the time of birth whether they have the intent to stay or not, including U.S. citizens by the way."

    Justice Ketanji Brown Jackson wondered, "So [are] we bringing pregnant women in for depositions? What are we doing to figure this out?"

    The justices also grilled Sauer about the landmark 1898 case of Wong Kim Ark, in which the U.S. Supreme Court ruled that Wong had birthright citizenship, because he was born in the United States. Sauer, however, maintained that Wong was only given birthright citizenship because his parents were legally domiciled in the United States.

    "I think even your brief concedes that the position you're taking now is a revisionist one with respect to a substantial part of our history," Justice Elena Kagan said. "That's, in part, because of Wong Kim Ark and the way people have read that case ever since then."

    Challenging the Trump birthright plan, the American Civil Liberties Union's Cecillia Wang told the Supreme Court that the 14th Amendment was enacted after the Civil War in order to have a universal rule of citizenship, subject to a closed set of exceptions, and that the birthright applies to all children born on U.S. soil.

    "We can't take the current administration's policy considerations into account to try to re-engineer and radically re-interpret the original meaning of the 14th Amendment," Wang argued.

    However, in reference to current perceived immigration problems versus those that existed at the time the 14th Amendment was enacted, Kagan posited: "What do we do if we think we have a new problem that didn't exist at the time of the 14th Amendment?"

    Justice Brett Kavanaugh followed up, asking whether the provisions of the 14th Amendment are frozen in place.

    Yes, replied Wang, because the framers of it were intent on putting the citizenship question out of the reach of Congress.

    The decision, expected by this summer, will almost certainly result in a historic ruling, and Trump himself made his mark at the court Wednesday morning.

    He became the first sitting president known to attend oral arguments, signaling the importance of this issue to him personally.

    After leaving the courtroom before the arguments were over, he wrote on Truth Social, "We are the only Country in the World STUPID enough to allow 'Birthright' Citizenship!" In fact, roughly three dozen countries offer it.

    Trump arrived about 10 minutes before the arguments began, listened to Sauer field the justices' questions for a little over an hour and then left a few minutes after Wang began to make her case.

    Outside the court, dozens of people rallied in support of birthright citizenship

    Volunteers with the ACLU, joined by immigrant rights organizations like CASA and the League of United Latin American Citizens, handed out fliers that read "protect birthright citizenship" and "14th Amendment."

    "We're all out here to protect the fundamental right of birthright citizenship. It's written in the 14th Amendment," said Anu Joshi, a staff member of the ACLU. "It's what makes us America."

    Among the crowd were several people who were citizens by birthright themselves.

    "I am a birthright citizen so this hits really, really close to home because without birthright citizenship I wouldn't even have my citizenship in the United States," said Stephanie Sanchez, a first-generation Mexican-American who came to the rally. "Here I am representing my community and fighting back."

    After the arguments, ACLU Executive Director Anthony Romero told the crowd he felt confident in the way the arguments played out inside.

    "We are fighting for the heart and soul of this country. The fight to protect birthright citizenship is about our neighbors, our families, our kids. It's not about the past, it's about the future," he said. "We will only accept what is just and what is right."

    Largely absent from the crowd were proponents of the president's position.

    Domenico Montanaro, Ximena Bustillo and Anusha Mathur contributed to this story.
    Copyright 2026 NPR

  • Sponsored message
  • O.C. Japan Fest, corgi beach day and more.
    A corgi dog runs through a field with its tongue out

    In this edition:

    O.C. Japan Fest, corgi beach day, the grunions are back, a new play festival, a talk with Sen. Cory Booker and more of the best things to do this weekend.

    Highlights:

    • Experience sakura season without leaving the area at the O.C. Japan Fair, featuring 250 vendors, craftspeople, food booths, art activities and more, all celebrating Japanese culture.
    • Check out readings of five new plays – all for free! – at the Play L.A. New Works Festival, put on by Stage Raw and the Greenway Arts Alliance along with a number of L.A. indie theater powerhouses.
    • Spend Friday night with New Jersey Senator Cory Booker, whose new book, Stand, tells stories from his political life that aim to share “actionable insights” to help preserve democracy in these challenging times.

    I hope you had luck in securing the first round of LA28 Olympics tickets — and that you’re not still waiting for page refreshes this morning! We’ve got all the info on how to get your tickets and why you shouldn’t fret if it doesn’t work out on this first try.

    LAist’s Mariana Dale went to Hollywood High School this week to see how students and teachers felt about Mitski bringing a concert to the historic space. Seems like no one was missing class since perfect attendance meant a shot at tickets.

    No matter your music taste, there’s a show for you this weekend. It may not be the height of summer yet, but things will be heating up at the Hollywood Bowl as Ben Platt and Rachel Zegler reunite for their concert performance of Broadway hit The Last Five Years. Plus, Licorice Pizza recommends Mercury Prize-winning London rapper Dave at the Palladium, St. Paul & the Broken Bones are at the Belasco, Calum Scott plays the Wiltern, and there’s a really cool First Fridays night at the Natural History Museum with dub legend Adrian Sherwood. Saturday has pop trio LANY at the Intuit Dome, Lamb of God slaughtering the YouTube Theater, SoundCloud rapper Rich Amiri at the Fonda, post-hardcore band Hail the Sun at the Wiltern, pop sensation Nessa Barrett at the Masonic Lodge, and another rising pop star, Alexander Stewart, at Chinatown’s cool new venue, Pacific Electric.

    Explore more from LAist: Check out the latest L.A. chefs who are nominated for a James Beard award, or follow the space trail if you were inspired by the new Ryan Gosling film, Project Hail Mary.

    Events

    O.C. Japan Fair

    April 3-5
    O.C. Fair & Event Center
    88 Fair Drive, Costa Mesa
    COST: FROM $16.78; MORE INFO

    Experience sakura season without leaving the area at the O.C. Japan Fair, featuring 250 vendors, craftspeople, food booths, art activities and more, all celebrating Japanese culture. From sake tastings to sushi-making workshops to musical performances and kimono try-ons, the annual event is one of the largest Japanese cultural fairs in California.


    Play L.A. New Works Festival 

    April 3-4
    Greenway Court Theatre
    544 North Fairfax Ave., Mid-City
    COST: FREE, MORE INFO

    Poster for PLAY LA Festival with the date April 3-4 2026
    (
    PLAY LA Festival
    )

    Check out readings of five new plays — all for free! — at the Play L.A. New Works Festival, put on by Stage Raw and the Greenway Arts Alliance, along with a number of L.A. indie theater powerhouses. This year’s plays are Stonewall’s Bouncer by Louisa Hill, produced by The Victory Theatre; At Olduvai Gorge by India Kotis, produced by The Odyssey Theatre Company; Ghost Play by Mathew Scott Montgomery, produced by InHouse Theatre; The Incident by Rachel Borders, produced by The Road Theatre Ensemble; and Three Dates by Erica Wachs, produced by IAMA Theatre Company. Go see one, or go see them all!


    SoCal Corgi Beach Day 

    Saturday, April 4, 10 a.m. to 3 p.m.
    21351 California 1, Huntington Beach 
    COST: FREE; MORE INFO 

    A corgi dog runs through a field with its tongue out
    (
    Vlad D
    /
    Unsplash
    )

    Head to Huntington Beach for the cutest event of the year, the annual SoCal Corgi Beach Day. This year’s theme is "Tiki Beach Pawty," because of course it is. Honor Queen Elizabeth II’s favorite pets and spend the day at the beach with these short, stout, snuggly friends while they frolic and compete in events like — I am not making this up – Corgi Limbo.


    Plaza Mexico Celebrates Easter 

    Sunday, April 5, 12:00 p.m. to 4 p.m.
    3100 E. Imperial Highway, Lynwood
    COST: FREE; MORE INFO 

    A poster for Plaza México Easter Celebration 2026
    (
    Plaza México
    )

    You have your pick of Easter Bunny photo ops and egg hunts around town, and Plaza Mexico would be a great one with the family. Meet and take a picture with the Easter bunny, enjoy kids' arts & crafts, family activities, vendors and sweet treats.


    Writers Bloc: Cory Booker

    Friday, April 3, 7:30 p.m.
    John Adams Middle School (JAMS) Performing Arts Center
    2425 16th St., Santa Monica
    COST: $33; MORE INFO

    Cory Booker seated looking past the camera
    NEW YORK, NEW YORK - FEBRUARY 05: Senator Cory Booker attends PBS' "Black & Jewish America: An Interwoven History" Screening With Henry Louis Gates, Jr. And Conversation With Sen. Cory Booker at 92NY on February 05, 2026 in New York City. (Photo by Jamie McCarthy/Getty Images)
    (
    Jamie McCarthy/Getty Images
    /
    Getty Images North America
    )

    Spend Friday night with New Jersey Senator Cory Booker, whose new book, Stand, tells stories from his political life that aim to share "actionable insights" to help preserve democracy in these challenging times. The conversation with Writers Bloc will be hosted by Sean Bailey, the former head of Walt Disney Studios Motion Picture Production for 14 years and the current CEO of the new multi-platform production company B5 Studios. The event is sold out, but there is a waitlist available.


    Behind the Canvas — An Exclusive Art Talk with the Jurors of A Woman's Place: Framing the Future

    Saturday, April 4, 11 a.m. 
    Ebell of Los Angeles 
    741 S. Lucerne Blvd., Mid-Wilshire
    COST: FREE; MORE INFO 

    Poster for the Behind the Canvas event
    (
    The Ebell
    )

    Have coffee and doughnuts with the curators of the Ebell’s Women’s History Month exhibit, "A Woman’s Place: Framing the Future." You can catch the show before it closes and see work from women artists exploring new interpretations of womanhood, feminism and art.


    Grunion Run 

    Saturday, April 4, starting at 10:30 p.m.
    Venice Breakwater
    Ocean Front Walk, Venice
    COST: FREE; MORE INFO 

    Piles of fish on the sand where the water meets. There are people crouching and taking pictures with their phones.
    Thousands of grunions on the shore.
    (
    Courtesy of the Cabrillo Marine Aquarium
    )

    I have lived in Venice for more than 20 years and never actually seen a grunion, despite efforts, but that doesn’t mean it’s not fun to see all your neighbors scouring the beach by moonlight on a Saturday night. The Venice Oceanarium folks always organize an educational tent with lessons on how these unique fish show up on our shores to reproduce, and maybe you’ll luck out and time it right this year.


    She’s Auspicious

    Saturday, April 4, 7 p.m.
    Broad Stage
    1310 11th St., Santa Monica
    COST: FROM $40; MORE INFO 

    L.A. native Mythili Prakash takes the Tamil dance form Bharatanatyam to new heights as a choreographer and performer. Her short dance film Mollika, commissioned by Sadler’s Wells Digital Stage in London, was nominated for a 2025 National Dance Award for Best Short Dance Film. She’s Auspicious, her latest production, "blurs the line between goddess and woman, exploring the dichotomy between celebration of the goddess versus the treatment of women in society." It was nominated for an Olivier Award in the category Best New Dance Performance in the U.K., and lucky for us, is on for one performance only at the Broad Stage in Santa Monica.

  • Trades workers say they're owed raises
    Diverse students walk on a concrete walkway with a glass pyramid in the background.
    Cal State Long Beach is one of the 23 CSU campuses where Teamsters-represented workers held a strike last month.

    Topline:

    The California Public Employment Relations Board (has issued a formal complaint against California State University trustees over the system’s alleged refusal to give raises to trades workers. The complaint follows a statewide strike earlier this year, in which workers at every campus walked off the job.

    Why it matters: Teamsters Local 2010 represents 1,100 plumbers, electricians, HVAC techs, locksmiths and other building maintenance staff who work across the CSU system. A formal complaint from the Public Employment Relations Board means the two parties must resolve the dispute in a formal hearing process.

    The backstory:  According to Teamsters Local 2010, union members won wage increases in 2024 “after nearly three decades of stagnation.” That year, the union was on the verge of striking alongside the system's faculty, but it reached a last-minute deal with the CSU. The union has filed an unfair labor practice charge against the system, arguing that the CSU refused to honor contractually obligated raises and step increases for its members.

    What the CSU says: The CSU maintains that conditions described in its collective bargaining agreement with the union — which “tied certain salary increases to the receipt of new, unallocated, ongoing state budget funding” — were not met.

    What’s next: In an emailed statement, spokesperson Amy Bentley-Smith said the CSU welcomes “the opportunity to present the facts of this case before an administrative law judge.” After the formal hearing, the state board will propose a resolution to the dispute.

    Go deeper: Trades worker union says CSU backtracked on contract, authorizes strike

  • Strong winds for some valleys and mountains
    A lone palm tree sways in the wind, its frond are pushed to its left side by a strong wind. A clear light blue sky can be seen behind it.
    Wind moves palm trees on Monday, Dec. 29, 2025, in Stanton.

    QUICK FACTS

    • Today’s weather: Mostly cloudy then sunny
    • Beaches: mid to upper 60s
    • Mountains: mid 60s to around 70 degrees
    • Inland: 64 to 71 degrees
    • Warnings and advisories: Wind advisory

        What to expect: A mostly sunny afternoon with temperatures sticking to the low to mid 70s for most of Southern California. Breezy conditions will pick up in the afternoon for some valleys and mountain communities.

        Read on ... for more details.

        QUICK FACTS

        • Today’s weather: Mostly cloudy then sunny
        • Beaches: mid to upper 60s
        • Mountains: mid 60s to around 70 degrees
        • Inland: 64 to 71 degrees
        • Warnings and advisories: Wind advisory

        The cool weather continues for one more day in Southern California. Later this evening, strong winds will kick in for some mountains and highway corridors ahead of a Santa Ana wind event slated for Friday.

        Temperatures at the beaches are going to stick around the mid to upper 60s, and around 70 degrees more inland.

        Coachella Valley, San Bernardino and Riverside County mountains will continue to see gusty winds until tonight.

        At noon, the Antelope Valley will be under a wind advisory, with winds expected to reach 20 to 30 mph, and some gusts up to 50 mph. Wind advisories will also kick in for the 5 Freeway corridor, Ventura County mountains and the Santa Susana mountains, where gusts could reach 45 mph.