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The Brief

The most important stories for you to know today
  • Yes, it exists, and we know where you can find it
    A brown square open paper container holds fries covered with gravy and melted cheese. A few fries are being held up by a white plastic knife, allowing the melted cheese to form strings to the other fries below. On the other side of the container there's a white plastic fork. It's sitting on a varnished wooden counter.
    Gooey, cheesy poutine

    Topline: 

    An introduction to poutine, the crown jewel of working class Quebecois cuisine, that’s not easy to find in L.A. We went on a search from Long Beach to Highland Park to find authentic purveyors of the dish, describing what they’re doing right, and what they’re doing that’s new.

    Why it matters: L.A.’s food world overflows with cultural diversity, with authenticity as a touchstone of some of the most celebrated restaurants, chefs and dishes. Poutine is not on a lot of menus, but seeing it emerge on more and more points to how authentic global cuisines are always welcome additions to the greater food scene.

    Why now: With the opening of Wavy Gravy, Southern California now has multiple restaurants that could be described as “poutineries," even if they don’t call themselves that. Are they getting the basics right?

    Poutine is sadly not a common dish at the diners and burger joints of greater L.A. If you’re unfamiliar with this touchstone of Quebecois cuisine, the basic formula is a plate of french fries, chunky cheese curds and a thin brown gravy.

    The gravy should be hot enough to melt the curds so you get a gooey pull of cheese with every forkful of fry. Like the chili fries of L.A.’s classic burger stands, Poutine is best enjoyed by fork. Also, like chili fries, this messy dish can be an indulgent side to a burger or a meal in itself.

    A pair of hands holds a bowl full of brown fries and blobs of cheese that are shiny from being bathed in gravy. One of the hands is also sticking a fork into the bowl.
    A popular Quebec dish called Poutine, consisting of french fries, cheddar cheese and gravy.
    (
    David Boily
    /
    AFP via Getty Images
    )

    Since originating at diners in rural Quebec in the 1950s, poutine is now common throughout Canada. Menus at many poutineries often include embellished versions, supplemented with toppings or transformed by subbing the gravy for another rich, heavy sauce.

    (Montreal’s Au Pied de Cochon, an icon of Quebecois cuisine, famously serves a foie gras poutine that melts in your mouth and travels directly to your arteries.)

    Attending college in Montreal in the early 2000s, I probably had it once a week, sometimes as post-bar drunk food, but often as a part of a bigger lunch or dinner (RIP to my early 20s metabolism).

    Every burger place, kabob shop, deli, diner and pizzeria had at least a simple version of poutine. Even Canada’s McDonalds has a poutine that’s hard to resist. “Do you want to upgrade your fries to a Poutine?” [think about it for a 10th of a second] “Yes. Yes, I do!”

    For years, when people asked me if there was poutine in L.A., I would point them to Jay’s Bar, a comforting strip-mall gastropub in Silver Lake that nailed the main three elements of the dish. But when a friend recently texted me the same question, I realized that Jay’s menu had switched to Japanese bar food.

    So where else to go? To find out, I've bounced from Santa Clarita to Long Beach, assessing the viscosity of various gravies, testing the elasticity of melted curds, and determining which restaurants make the most delicious poutines in the region.

    Here’s what I found:

    The Kroft (Anaheim, Chinatown, Long Beach)

    A small, open white box houses brown gravy, curds and fries, adorned with pickled red onions, sauteed mushrooms on top of braised beef.
    The braised beef poutine from The Kroft in Chinatown.
    (
    Henry Goldman
    )

    Walking into the Kroft’s Chinatown outpost, nestled into one of the new apartment buildings at the Chinatown Gateway Monument, I was slightly skeptical. The counter-service restaurant, with outposts in L.A., Long Beach and Anaheim, had a sign in their window that announced they serve poutine. But then, in parentheses, the sign described poutine as “loaded fries.”

    Now, it’s true that poutine is similar to loaded fries — I would contend they might even be culinary cousins. But this description negates poutine’s identity as a category unto itself. It would be like a sign describing nachos as “chips and dip.” It undermines the dish’s power.

    However, once I took in the plethora of authentic-looking poutines on the menu, I relaxed a bit. Even though they sell burgers, this place could qualify as a poutinerie, a restaurant that makes poutine the star of their menu. In addition to a basic poutine, they serve some very appetizing variations, like a loco moco poutine with wagyu beef and fried eggs. And a country fried chicken poutine, which adds chicken nuggets and swaps out the brown gravy for a country sausage gravy.

    I was blown away by the braised beef poutine, which, in addition to brown gravy, curds and fries, adds pickled red onions, sautéed mushrooms and the titular braised beef to make an oozy carb bomb. The double-fried french fries are crisp enough to not immediately turn soupy when hit with the gravy, but the gravy is not so hot that it scalds your mouth. It is also rich, complex, and the braised beef blends perfectly with the overall dish. A strong contender.

    Locations and hours:

    Anaheim:
    440 S. Anaheim Blvd., Anaheim
    Sunday through Thursday, 11 a.m. - 9 a.m. Friday through Saturday, 11 a.m.-10 p.m.

    Long Beach:
    The Hanger LBX, 4150 McGowan St., Unit 15, Long Beach
    Sunday through Thursday, 11 a.m. to 8:30 a.m., Friday through Saturday, 11 a.m.- 9 a.m.

    Chinatown:
    629 N. Broadway, Los Angeles
    Monday through Wednesday, 11:30 a.m. - 9 p.m. Thursday through Saturday, 11:30 a.m. - 10 p.m., Sunday, 11:30 a.m - 9:30 a.m.

    Sideburns, Long Beach 

    Two pictures side by side. Left: A container of poutine — fries, cheese and gravy — with a fork stuck in it sits on a table. Right: The entrance to a place called "Sideburns," as noted from a sign above the doorway in thick, yellow script.
    (
    Henry Goldman
    )

    During the pandemic, The Stache Bar, the platonic ideal of a neighborhood dive located near downtown Long Beach, opened up Sideburns in the space next door. It’s a humble counter-service burger joint, with a menu that lends itself to food that works well before the bar, after the bar and during the bar.

    Sideburns has a lot of mouthwatering offerings, including a classic poutine. (They also have a “poutine burger,” which is exactly what it sounds like, a burger with poutine on it, which I will have to try for another article).

    We initially ordered in the restaurant, but realized we could eat at the bar, so made the trek next door to eat our food with a cold beer. Nothing makes me feel quite like a grown-up then walking into a dark dive on an excessively bright day.

    After a short wait, the bartender dropped a tremendous classic poutine on the bar. Size-wise, it’s closer to a side poutine than a meal. I suspect that's because if the bar was serving full plates of poutine, they would immediately put their customers to sleep. The poutine itself hits all the important notes: a brown gravy that lingers on the tongue, thick curds that melt nicely, and crisp, kennebec fries. After cleaning the paper tray the poutine came in, I was envious of the locals who get to call this lovely dive their neighborhood watering hole.

    Location: 941 East 4th St., Long Beach

    Hours: 11 a.m. - 12 a.m. (every day)

    Wavy Gravy, Highland Park  

    Two photos side by side, both displaying versions of poutine, which consists of fries, cheese and gravy.
    Poutine from Wavy Gravy in Highland Park.
    (
    Henry Goldman
    )

    A newish, gravy-forward restaurant in Highland Park, Wavy Gravy has enough varieties of poutine on the menu that it could reasonably be called a poutinerie — if that term meant anything to Southern California restaurant-goers.

    However, they also serve plenty of burgers, sandwiches and all-day breakfast items, so their framing as a “diner” also fits. The counter service restaurant on York has a retro aesthetic, a comfortable vibe and I suspect some Canadian roots. There was a stack of Nanaimo bars (a chocolatey cookie bar originally from British Columbia), in a display case next to a small Canadian flag. They also know their poutine.

    Of the L.A. County poutines I tried, I think Wavy Gravy has my favorite gravy, which is a happy development for a restaurant with “gravy” in its name. It was rich and decadent and was also the perfect temperature to melt the square-ish curds on the poutine. The fries were also perfectly fried — initially crispy but soft enough inside to melt in your mouth a few moments after biting into them.

    After trying the basic poutine, I came back for their taco poutine with grilled chicken. I was curious to discover how it incorporated Mexican flavors into this decidedly Quebecois dish. The answer? Not very well. Nonetheless, the poutine was delicious, but it would have been better called a “marinated chicken poutine” rather than a “taco poutine”. That’s all to say, I still heartily recommend Wavy Gravy as one of the finest purveyors of poutine I’ve found in Southern California. I look forward to returning and trying more of the varieties on the menu.

    Location: 5805 York Blvd., Highland Park

    Hours: Monday, Tuesday, Thursday and Friday, 9:30 a.m. - 2:30 p.m. and 5 p.m. - 9 p.m.
    Saturday, 9 a.m. - 9 p.m.; Sunday, 9 a.m. - 8 p.m.

    I’m definitely hoping that these and other restaurants will create a new generation of poutine aficionados in and around L.A., and will push chefs to try new iterations on a classic dish. But even if it remains niche and only on a few menus, I'll still return to these recommended spots, hoping for that perfect, gravy-soaked cheese-pull.

  • How does a city get its own game?
    A photo of a Long Beach version of Monopoly
    Long Beach is the latest SoCal city to get its own Monopoly game

    Topline:

    A new Long Beach-themed Monopoly game turns local landmarks into playable spaces on the board. The game is part of a recent wave of city-specific editions that has the iconic game connecting with communities through nostalgia and local pride.

    How to get a Monopoly game: To be featured, a city has to have enough people excited enough to support the production of thousands of games.

    Why now: Top Trumps has expanded U.S. city editions in recent years as interest in board games has resurged after the pandemic. A company representative said that Long Beach, with its strong sense of community and recognizable landmarks, fit the model.

    Monopoly lovers can now buy up the Queen Mary, collect rent on Belmont Shore and park their token at a storied tattoo shop, Outer Limits.

    The Long Beach landmarks line the spaces of a new Monopoly edition themed around L.A. County’s second biggest city, released just this month.

    The Long Beach edition is part of an expanding series of Monopoly games featuring dozens of American cities, which Hasbro licensee Top Trumps started to produce about five years ago when interest in board games surged during the pandemic.

    What it takes to make the cut

    How does a city land on one of the world's most popular board games? Turns out, it’s not just a roll of the dice.

    “We’re looking for places with strong community pride, places where people will really love seeing their city on a Monopoly board,” said Jennifer Tripsea, a partnership sales executive with Top Trumps.

    Long Beach fit the bill and got to join a list of SoCal cities on Monopoly boards including Huntington Beach, Riverside and Palm Springs.

    Tripsea said in some instances, a city will pitch themselves to the company — she didn’t disclose which have — but not every place makes the cut.

    There has to be enough population — or local enthusiasm — to support a run of thousands of games.

    Top Trumps sells the games online and through local businesses, sometimes the same ones featured on the board. That creates a built-in customer base: residents, tourists and collectors hunting for their next addition.

    And while some businesses may offer to sponsor their way into consideration, their inclusion isn’t a given.

    Tripsea said when deciding who earns a spot, the company weighs cultural relevance, brand standards and community input.

    The community gets a turn

    Once a city is selected, residents are invited to help shape the board.

    That means emailing suggested landmarks and drafting potential Chance and Community Chest cards. For Long Beach, one Community Chest card directs players to collect $100 if they "attend a beach cleanup at Alamitos Beach."

    Hundreds of submissions flooded in over the last year, many pointing to the same top attractions, Tripsea said. The Queen Mary and Aquarium of the Pacific take up the same spots on the board that are occupied by Park Place and Boardwalk in the original game.

    A shot of an ocean liner marked as the "Queen Mary."
    Of course the Queen Mary historic ocean liner landed a plum spot on the Long Beach version of Monopoly.
    (
    Patrick T. Fallon
    /
    Getty Images
    )

    Others featured on the board are lesser known to outsiders, like Rosie’s Dog Beach and the Arts Council for Long Beach.

    The arts nonprofit was “surprised and excited” to hear from Top Trumps last year that they were being included in a version all about Long Beach, said interim executive director Lisa DeSmidt.

    “I describe Long Beach as a big city that's run like a small town, and that everybody kind of knows each other to some degree,” DeSmidt said. “Long Beach has a sense of community in that Long Beach takes care of Long Beach people.”

    A yellow Monopoly piece that reads "Arts Council for Long Beach" and features tiny renderings of buildings, a palm tree and ferris wheel.
    An intern for the Arts Council for Long Beach designed its space on the Monopoly board.
    (
    Arts Council for Long Beach
    )

    An intern for the arts council, Peyton Smith, designed its space on the board, featuring small, intricate renderings of landmarks like the Long Beach Airport and the pyramid arena at Cal State Long Beach.

    For DeSmidt, the game serves as a kind of cultural snapshot highlighting the city’s mix of arts, neighborhoods and institutions. It’s reminiscent of the council’s own project mapping the city’s cultural assets.

    “This ties into uplifting what makes Long Beach unique and what people love about it,” DeSmidt said.

    Monopoly's lasting pull

    Outer Limits Tattoo was also invited to be part of the game, where it now appears next to VIP Records on the board.

    Recognized as the country’s oldest continuously working tattoo shop, Outer Limits’ history dates back to 1927, when it opened in the waterfront amusement district known as The Pike, now home to the Pike Outlets.

    Outer Limits' general manager Matt Hand said once word got out that the shop was stocking the game, customers started showing up just to buy it.

    “It’s just a cool thing,” Hand said. “Especially when it’s like, ‘The business where I get tattooed’ is on the board.”

    A big reason Hand thinks these editions are catching on is nostalgia. Seeing your own city in a board game that you played as a kid — and may be now playing with your own kids — is thrilling.

    “You're basically like a part of the game now,” Hand said.

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  • Why you are seeing purple early this year
    Pedestrians and a dog walker stroll a street in South Pasadena that is lined by Jacaranda trees in full bloom.
    Jacaranda trees line a street in South Pasadena.

    Topline:

    You might have noticed a little more purple on your commute in Los Angeles recently. Turns out the jacarandas are putting on their annual show of blooms a little early this year.

    Why? Originally from the tropics, jacarandas respond to changes in temperature. They typically flower in our region from late April to mid-June. But remember that sweltering heat wave we got in March?

    Where are the purple hot spots? A couple years ago, a local data graphics editor created an interactive map so you can find the purple hot spots.

    Go deeper: Jacaranda season is upon us. But wait, how do you pronounce ‘jacaranda’?

    You might have noticed a little more purple on your commute in Los Angeles recently. Turns out the jacarandas are putting on their annual show of blooms a little early this year.

    Originally from the tropics, jacarandas respond to changes in temperature. They typically flower in our region from late April to mid-June.

    But remember that sweltering heat wave we got in March?

    “They got the clear sign: ‘It’s over 90 [degrees], it’s hot out. Even though you weren’t quite prepared, it’s time to put out some flowers,'” Loral Hall, community forestry senior program manager at environmental nonprofit TreePeople, told LAist.

    Hall said not only do jacarandas grace us every year with thick canopies and carpets of purple, they’re relatively drought tolerant, pest resistant and able to grow in urban areas (like in a small square patch of dirt surrounded by concrete).

    “They’re attention-grabbers here in Southern California,” said Hall, who grew up in Hollywood and has childhood memories of playing with the fallen purple blooms at a local park. “In a place where we don’t have really obvious seasons, [jacaranda blooms] are a sign that warmer weather is on the way.”

    Hall also shared a lesser-known fact about jacarandas: There’s a white cultivar, too. The white version is much more rare in L.A., though with some of the trees rumored to be in a non-public area of the L.A. County Arboretum, Hall said.

    A jacaranda tree is full of purple booms. The blooms have dropped onto a pond below, making a purple carpet.
    A jacaranda at the LA Arboretum.
    (
    Katherine Garrova
    )

    How’d they get here? 

    The jacaranda is native to the tropical and subtropical regions of Argentina and Brazil.

    While we don’t know exactly when the jacaranda first arrived in our area, we do know they were brought to Southern California in the late 19th century and proliferated thanks to a local horticulturist named Kate Sessions.

    Where are the purple hot spots? 

    A couple years ago, a local data graphics editor even created an interactive map so you can find the purple hot spots.

    They’re... everywhere, so it shouldn’t be too hard to stumble upon a jacaranda show.

  • 29 migrants have died in ICE custody since October

    Topline:

    The number of immigrants who have died while in Immigration and Customs Enforcement custody has reached an all-time high this fiscal year.

    Where things stand: Twenty-nine people have died in ICE custody since October, the start of the federal government's fiscal year, already surpassing 2004's toll of 28, the previous record, according to government data. There are about 60,000 people currently in immigration detention.

    Facilities in Texas and California are the deadliest: Adelanto ICE Processing Center in Adelanto, Calif., and Camp East Montana in El Paso, Texas have each reported the deaths of three detainees, the most out of ICE's sprawling detention operation. 

    The number of immigrants who have died while in Immigration and Customs Enforcement custody has reached an all-time high this fiscal year.

    Twenty-nine people have died in ICE custody since October, the start of the federal government's fiscal year, already surpassing 2004's toll of 28, the previous record, according to government data.

    The most recent death was of 27-year-old Aled Damien Carbonell-Betancourt, a Cuban man held in ICE custody in Miami. According to an initial report released by ICE on the evening of April 16, Carbonell-Betancourt was found unresponsive in his cell on the morning of April 12. The report lists the cause of death as a "presumed suicide," but the official cause remains under investigation.

    The report said Carbonell-Betancourt entered the United States in 2024 without valid documents and later released into the U.S. via a program known as parole, which allows noncitizens to enter the country without a formal visa, often for humanitarian reasons.

    He was arrested for resisting an officer with violence in 2025, and then transferred into ICE custody earlier this year, according to the ICE release.

    The rise in deaths comes as detention numbers have skyrocketed during the Trump administration. Detentions are up more than 70% under President Donald Trump compared to the first year of the Biden administration. The Trump administration has carried out an unprecedented crackdown on immigration. Immigration officers have arrested and detained criminals in the country illegally, as well as many people without a criminal record and some migrants who are in the country with temporary protections from deportation.

    There are about 60,000 people currently in immigration detention.

    In a statement to NPR, DHS denied there's been a spike in deaths and attributed the increase to the large number of people in detention. DHS said as of April 16, "death rates in custody under the Trump administration are 0.009% of the detained population."

    The agency added that ICE provides migrants with access to medical care.

    "For many illegal aliens this is the best healthcare they have received their entire lives," the statement said. The statement went on to encourage detainees to self-deport. "Being in detention is a choice. We encourage all illegal aliens to take control of their departure with the CBP Home App," the statement said.

    Loading...

    During a congressional hearing also on Thursday, acting ICE Director Todd Lyons said there are a high number of deaths this fiscal year "because we do have the highest amount in detention that ICE has ever had since its inception in 2003." Lyons added that the agency spent "almost half a billion dollars last fiscal year … to ensure that people have proper care."

    He reiterated details noted by other DHS officials: that detainees get a complete physical within 14 days and are seen by a medical professional within 24 hours of being admitted.

    "No death is what we want. We don't want anyone to die in custody," Lyons, who handed in his resignation hours after testifying, said. "I hope that's a policy of anyone that has to be tasked with detaining someone."

    When asked how many people were still working in the Office of Detention Oversight, he was not able to provide a number.

    Lyons was also asked about the delay in public reporting and tracking detainee deaths. On April 13, Georgia Democratic Sens. Jon Ossoff and Raphael Warnock sent a letter to Lyons and DHS Secretary Markwayne Mullin raising concern over the rising number of detainee deaths and noted that of the 49 deaths in custody at the time since January 2025, "ICE has issued an interim death notice within 48 hours in only 15 cases" and argued that reports contained less details.

    "We are reporting. We are working on that timeline," Lyons said during the House hearing, agreeing that the detainee death reports were considered essential work even during the agency's funding lapse.

    Facilities in Texas and California are the deadliest

    Adelanto ICE Processing Center in Adelanto, Calif., and Camp East Montana in El Paso, Texas have each reported the deaths of three detainees, the most out of ICE's sprawling detention operation. 

    Listen 24:32
    Rotten food, disease, isolation. What we know about conditions at the Adelanto ICE detention center
    LAist's Julia Barajas reports on detainee experiences at Adelanto and how California lawmakers are trying to enforce accountability.

    According to ICE's initial reports, the deaths of the six immigrant detainees were attributed to a number of causes, including suicide, alcohol withdrawal, liver failure and kidney failure. Other detainees displayed symptoms like shortness of breath.

    One of the deaths at Camp East Montana was ruled a homicide by the El Paso County Medical Examiner's Office.

    Initially, DHS said that Geraldo Lunas Campos had died in Camp East Montana after experiencing "medical distress." It also claimed Lunas Campos had become "disruptive while in line for medication" and was placed in segregation. But later, the El Paso Medical Examiner's Office ruled his death a homicide due to "asphyxia due to neck and torso compression." The FBI is now investigating the death.Chris Benoit, an attorney representing the family, told NPR Lunas Campos came to the U.S. in the mid-1990s as part of a wave of Cubans immigrants during the balsero crisis after the fall of the Soviet Union.

    "For all sense and purposes he is an American," Benoit said. "He's lived here for decades and raised his family here and his kids love him and miss him."

    According to DHS, Lunas Campos had been convicted of multiple crimes, including petty larceny, unlawful possession of a weapon during a robbery and sexual contact with a child under 11.

    In a court petition seeking eyewitness testimony, Lunas Campos' three children said they planned to file a wrongful death lawsuit.

    Rahul Mukherjee contributed to this report.
    Copyright 2026 NPR

  • Harder to fight bacterial and viral infections
    a white fungus grows in a petri dish on a countertop
    This is a strain of Candida auris cultured in a petri dish at a laboratory at the Centers for Disease Control and Prevention. It's a form of yeast that can harm humans — and is resistant to the most common antifungal drugs.

    Topline:

    Combatting bacterial and viral infections is getting tougher because of their growing resistance to drugs. Antibiotic drugs can no longer be counted on to conquer nasty bacteria. Antivirals don't always overpower the viruses. This is a huge problem but it is one that widely acknowledged and researched.

    Why it matters: Fungicides are used to protect plants against fungal disease. Everything — watermelons, maize, wheat, flowers — use lots of fungicides. If we didn't use the fungicides, you'd probably have a yield loss maybe of 30% or 40%.

    The problem is that the fungicides are quite similar to the drugs we give to patients. So the fungus becomes resistant to the fungicide and, at the same time, our medical azoles [a class of antifungal drugs] do not work as well anymore.

    Read on ... for more on the problem with fungicides and what can be done about them.

    Combatting bacterial and viral infections is getting tougher because of their growing resistance to drugs. Antibiotic drugs can no longer be counted on to conquer nasty bacteria. Antivirals don't always overpower the viruses. This is a huge problem but it is one that widely acknowledged and researched.

    There's an additional medical challenge though, that matters a lot. Namely, drug-resistant fungi.

    Yep, fungi.

    It's a topic that doesn't get discussed much — and that worries Paul Verweij, professor of clinical mycology at Radboud University Medical Center in Nijmegen, the Netherlands. He says there's a "silence surge" in drug-resistant fungi and that it's mostly happening under-the-radar.

    This is a particular challenge in lower-income countries.

    "Look at, for instance, Candida auris [a type of yeast that can cause severe infections and is often drug-resistant] -- you need very, very strict infection control measures in hospitals, you need good diagnostics, good infection control, you have to follow-up with patients and that's just not available in these lower- middle-income countries," he says. "People will die, and you won't know they have a fungal infection. You wouldn't know if it was resistant."

    Verweij teamed up with 50 scientists around the world – from Brazil to Nigeria to China — to call for action against drug‑resistant fungi in Nature Medicine this week.

    NPR spoke with Verweij, who's been working on this issue for more than 20 years. His interview has been edited for length and clarity.

    What's the link between agriculture and drug-resistant fungi?

    Fungicides are used to protect plants against fungal disease. Everything — watermelons, maize, wheat, flowers — use lots of fungicides. If we didn't use the fungicides, you'd probably have a yield loss maybe of 30% or 40%.

    The problem is that the fungicides are quite similar to the drugs we give to patients. So the fungus becomes resistant to the fungicide and, at the same time, our medical azoles [a class of antifungal drugs] do not work as well anymore.

    The fungi which cause disease in humans are not causing disease in plants. So this is an unintended effect.

    How does the resistance get from farms to hospitals? 

    So the molds – the hairy fungi – have spores which are released into the air. These spores travel long distances. It's not really well-understood but the idea is that they go right up to these jet streams, very high into the atmosphere and then can travel for continents. We inhale the spores all the time.

    How serious are fungal infections?

    With fungi you have two types of infections. First, we have very severe infections, and they usually occur in [hospitalized] patients who have some kind of defect in their immunity. So, yeast found in the bloodstream or mold in the lungs. Second, we have infections of the skin, the hair and the nails, which are irritating but are not life threatening.

    In the past 10 to 20 years, we see more and more resistance in fungi in both those categories.

    There are very few studies looking at the clinical impact. We did a study in the Netherlands, and we found that if you compare an infection [where azole antifungal drugs work] and where it's resistant. There's about a 20% difference in mortality — you're 20% more likely to die. So that's a significant impact. And there's the new skin disease [Trichophyton indotineae] where you don't have mortality but we've had patients who have been on treatment for four years and are still suffering from the infection.

    Why is it hard to create new antifungals?

    The main challenge is that fungi, if you look at the cell structure — how they are built up — it's very similar to the human cell. This is different from bacteria, because bacteria are much simpler. And viruses are even more simple because they don't even have a cell.

    For fungi, because they're similar to human cells, it's quite difficult to find a drug which kills the fungus but does not harm the human cell. So in the past 75 years, we have developed only five classes of antifungals. The azoles are, by far, the most important.

    The problem is that if you can't use one of these classes then maybe you'll have one alternative left. It's already causing problems. For instance, if the fungus is in the brain, you have a very few drugs which actually get into the brain.

    What can be done?

    At a mycology meeting we found a global community who wanted to collaborate [on this issue].

    For example, you really want to know what people are using [on crops] and see if you can reduce that or if there's any unnecessary use. Another important factor is: If you introduce new fungicides, they [should] undergo an assessment to see their impact on human fungal pathogens. It's important to establish if there's a risk for cross resistance.

    Are you optimistic? 

    I've worked in this field for a long time, and I think that it is changing.

    WHO published a fungal pathogen list in 2022 for the first time — that had a major impact. A decade ago, when the World Health Organization came out with its global action plan against antimicrobial resistance, fungi were only mentioned twice. Now, after 10 years, it is being revised. And as a mycology community, we feel it is really important now that fungi are addressed.

    The problem is, in fungi, we need to do the basic stuff: Develop the tools. Do the surveillance. Set up the [laboratory] networks. And it's sometimes difficult to get these basic things funded.

    But overall, I think it's really changing. People are realizing this is not a local problem — it's really global.