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The Brief

The most important stories for you to know today
  • LA County dispatches specialists for evacuees
    Several ambulances and emergency response vehicles are parked on a one way street in front of a large lit building. People can be seen going down stairs towards the street.
    The Pasadena Convention Center normally hosts home shows, comic cons, and trade shows, but it was transformed into an evacuation site with hundreds of cots — one of at least 13 shelters opened to serve more than 200,000 residents under evacuation orders from the Los Angeles fires.

    Topline:

    Local health departments have become a key part of governments’ response to wildfires, floods, and other extreme weather events, which scientists say are becoming more intense and frequent due to climate change.

    Why it matters: Wildfires have become a recurring experience for many Angelenos, making it difficult for people to feel safe in their home or able to go about daily living, said Lisa Wong, director of the Los Angeles County Department of Mental Health.

    Why now: The convention center in downtown Pasadena, which normally hosts home shows, comic cons, and trade shows, was transformed into an evacuation site with hundreds of cots. It was one of at least 13 shelters opened to serve more than 200,000 residents under evacuation orders.

    Read on... for more on the mental health support following the recent fires.

    As Fernando Ramirez drove to work the day after the Eaton Fire erupted, smoke darkened the sky, ash and embers rained onto his windshield, and the air smelled of melting rubber and plastic.

    He pulled to the side of the road and cried at the sight of residents trying to save their homes.

    “I could see people standing on the roof, watering it, trying to protect it from the fire, and they just looked so hopeless,” said Ramirez, a community outreach worker with the Pasadena Public Health Department.

    A man with medium skin tone wearing a black sweater and t-shirt looks at the camera. To his left are staff and people near carts of water by doors and large windows.
    Fernando Ramirez, an outreach worker with the Pasadena Public Health Department, circulated around the city’s evacuation site on Jan. 8, 2025, offering mental health support. He said one of the hardest parts of his shift was helping people look for missing loved ones.
    (
    Molly Castle Work/KFF Health News
    )

    That evening, the 49-year-old volunteered for a 14-hour shift at the city’s evacuation center, as did colleagues who had also been activated for emergency medical duty. Running on adrenaline and little sleep after finding shelter for homeless people all day, Ramirez spent the night circulating among more than a thousand evacuees, offering wellness checks, companionship, and hope to those who looked distressed.

    Local health departments, such as Ramirez’s, have become a key part of governments’ response to wildfires, floods, and other extreme weather events, which scientists say are becoming more intense and frequent due to climate change. The emotional toll of fleeing and possibly losing a home can help cause or exacerbate mental health conditions such as anxiety, depression, post-traumatic stress disorder, suicidal ideation, and substance use, according to health and climate experts.

    Wildfires have become a recurring experience for many Angelenos, making it difficult for people to feel safe in their home or able to go about daily living, said Lisa Wong, director of the Los Angeles County Department of Mental Health. However, with each extreme weather event, the county has improved its support for evacuees, she said.

    For instance, Wong said the county deployed a team of mental health workers trained to comfort evacuees without retraumatizing them, including by avoiding asking questions likely to bring up painful memories. The department has also learned to better track people’s health needs and redirect those who may find massive evacuation settings uncomfortable to other shelters or interim housing, Wong said. In those first days, the biggest goal is often to reduce people’s anxiety by providing them with information.

    “We've learned that right when a crisis happens, people don't necessarily want to talk about mental health,” said Wong, who staffed the evacuation site Jan. 8 with nine colleagues.

    Instead, she and her team deliver a message of support: “This is really bad right now, but you're not going to do this alone. We have a whole system set up for recovery too. Once you get past the initial shock of what happened — initial housing needs, medication needs, all those things — then there's this whole pathway to recovery that we set up.”

    The convention center in downtown Pasadena, which normally hosts home shows, comic cons, and trade shows, was transformed into an evacuation site with hundreds of cots. It was one of at least 13 shelters opened to serve more than 200,000 residents under evacuation orders.

    The January wildfires have burned an estimated 64 square miles — an area larger than the city of Paris — and destroyed at least 12,300 buildings since they started Jan. 7. AccuWeather estimates the region will likely face more than $250 billion in economic losses from the blazes, surpassing the estimates from the state’s record-breaking 2020 wildfire season.

    Lisa Patel, executive director of the Medical Society Consortium on Climate and Health, said she’s most concerned about low-income residents, who are less likely to access mental health support.

    “There was a mental health crisis even before the pandemic,” said Patel, who is also a clinical associate professor of pediatrics at Stanford School of Medicine, referring to the covid-19 pandemic. “The pandemic made it worse. Now you lace in all of this climate change and these disasters into a health care system that isn't set up to care for the people that already have mental health illness.”

    Early research suggests exposure to large amounts of wildfire smoke can damage the brain and increase the risk of developing anxiety, she added.

    At the Pasadena Convention Center, Elaine Santiago sat on a cot in a hallway as volunteers pulled wagons loaded with soup, sandwiches, bottled water, and other necessities.

    Santiago said she drew comfort from being at the Pasadena evacuation center, knowing that she wasn't alone in the tragedy.

    A woman with medium skin tone wearing a black shirt sitting on a chair looks towards the camera. Behind her is a cot with various items and people in the background.
    Elaine Santiago had been celebrating her 78th birthday with family when she fled her home in the small city of Sierra Madre, east of Pasadena, on the night of Jan. 7, 2025. She drew comfort from being at the evacuation site. “It sort of gives me a sense of peace at times,” she says. “Maybe that’s weird. We’re all experiencing this together.”
    (
    Molly Castle Work
    /
    KFF Health News
    )

    “It sort of gives me a sense of peace at times,” Santiago said. “Maybe that’s weird. We’re all experiencing this together.”

    She had been celebrating her 78th birthday with family when she fled her home in the small city of Sierra Madre, east of Pasadena. As she watched flames whip around her neighborhood, she, along with children and grandkids, scrambled to secure their dogs in crates and grabbed important documents before they left.

    The widower had leaned on her husband in past emergencies, and now she felt lost.

    “I did feel helpless,” Santiago said. “I figured I’m the head of the household; I should know what to do. But I didn't know.”

    Donny McCullough, who sat on a neighboring green cot draped in a Red Cross blanket, had fled his Pasadena home with his family early on the morning of Jan. 8. Without power at home, the 68-year-old stayed up listening for updates on a battery-powered radio. His eyes remained red from smoke irritation hours later.

    A man with dark skin tone and a grey beard wearing a white t-shirt and hat sits on a chair and looks at the camera. To his right are blankets that have text that reads "American Red Cross"
    Donny McCullough, a music producer, says it was difficult to put on a brave face for his wife and daughters while fleeing their Pasadena home the morning of Jan. 8, 2025.
    (
    Molly Castle Work
    /
    KFF Health News
    )

    “I had my wife and two daughters, and I was trying not to show fear, so I quietly, inside, was like, ‘Oh my God,’” said McCullough, a music producer and writer. “I’m driving away, looking at the house, wondering if it’s going to be the last time I’m going to see it.”

    He saved his master recording from a seven-year music project, but he left behind his studio with all his other work from a four-decade career in music.

    Not all evacuees arrived with family. Some came searching for loved ones. That’s one of the hardest parts of his shift, Ramirez said. The community outreach worker helped walk people around the building, cot by cot.

    A week in, at least two dozen people had been killed in the wildfires.

    The work takes a toll on disaster relief workers too. Ramirez said many feared losing their homes in the fires and some already had. He attends therapy weekly, which he said helps him manage his emotions.

    At the evacuation center, Ramirez described being on autopilot.

    “Some of us react differently. I tend to go into fight mode,” Ramirez said. “I react. I run towards the fire. I run towards personal service. Then once that passes, that's when my trauma catches up with me.”

    Need help? Los Angeles County residents in need of support can call the county’s mental health helpline at 1-800-854-7771. The national Suicide & Crisis Lifeline, 988, is also available for those who’d like to speak with someone confidentially, free of charge.

    This article was produced by KFF Health News, a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF — the independent source for health policy research, polling, and journalism. KFF Health News is the publisher of California Healthline, an editorially independent service of the California Health Care Foundation.

  • Built by kids to learn native tongues

    Topline:

    Many Native American languages are endangered. With the help of his mentor, a 12-year-old in Michigan hopes to help preserve his language through robotics.

    Why it matters: U.S. Indian boarding schools played a major role in the loss of Indigenous languages. Children separated from their families were taught, sometimes violently, not to speak their native tongues, and many did not pass them on to their children.

    Today, some Native youth are learning their languages in schools. That's why SkoBot was invented.

    SAULT STE. MARIE, Mich. — The idea came to Danielle Boyer in a toy store. The inspiration? It was Tickle Me Elmo.

    "Whenever you'd press his belly, he would talk, and he would teach you things," she said. "There are toys that teach us in English, but there aren't toys that teach us Anishinaabemowin. And I wanted that to be different."

    Anishinaabemowin includes the Potawatomi, Odawa and Ojibwe languages. Exact estimates vary, but there are fewer than 10,000 people in the U.S. who speak Anishinaabemowin. That number is around 25,000 in Canada. Some Native languages have just a few dozen fluent speakers, while others have none.

    Boyer has seen how quickly language loss can happen. Her grandmother speaks Anishinaabemowin, but she is one of the last fluent speakers of their dialect.

    "It is devastating to feel like your language could be lost," said Boyer, a member of the Sault Ste. Marie Tribe of Chippewa Indians. "You lose your culture, you lose a way to describe who you are."

    U.S. Indian boarding schools played a major role in the loss of Indigenous languages. Children separated from their families were taught, sometimes violently, not to speak their native tongues, and many did not pass them on to their children.

    Today, some Native youth are learning their languages in schools. But Boyer said many of them still aren't invested. "They see it as another homework assignment."

    A woman in glasses talking to a tween in glasses in front of a laptop.
    Boyer and Hoy work on some last-minute adjustments to his AI-powered SkoBot before presenting at his school's end-of-year showcase, called the STEAM Museum.
    (
    Kadin Mills
    /
    NPR
    )

    That's why she invented the SkoBot. It's a customizable toy robot designed to get Indigenous children excited to learn their languages.

    "I can say 'Hey SkoBot, what is bear?' And it will say, 'Bear is makwa, makwa,' and it'll repeat it, right? So I can say, 'What is crane?' It'll say, 'Crane is ajijaak, ajijaak.'"

    SkoBots use a form of artificial intelligence to speak Indigenous languages, and they're small enough to mount on the user's shoulder. They sort of resemble mini R2-D2 droids, from Star Wars, except these robots are designed to look like woodland creatures and decorated in Native American florals.

    Through a nonprofit she started when she was 18, Boyer, now 25, has mentored hundreds of Native American children across the country, teaching them to build SkoBots of their own. One of them is 12-year-old Holden Hoy in Michigan's Upper Peninsula.

    "I was already a big fan of robotics and how they work, how you can bring inanimate objects to life," he said. "And I'm Ojibwe, and so I've always wanted to save the Ojibwe language."

    Hoy, a rising seventh-grader, showed off his design at an end-of-the-year science fair at his school, JKL Bahweting Anishinaabe School in Sault Ste. Marie. Like Boyer, he is a member of the Sault Tribe.

    He programmed his SkoBot to answer three questions ahead of his presentation. One of them was, "What's your name," to which the robot would respond in Hoy's voice: "Aaniin, Hello. Sabe indizhinikaaz, Bahweting indoonjibaa. I was built by Holden Hoy. I will not gain sentience and take over the world. Or will I?"

    Hoy named his SkoBot Sabe, which means Bigfoot in Anishinaabemowin. In Ojibwe culture, Bigfoot represents honesty, one of seven sacred teachings.

    His classmates and their parents stopped by his booth to see Sabe in action. Boyer was there too, helping Hoy with his presentation.

    "I'm very happy that people are actually coming to this booth," Hoy said. "I'm happy that they are learning things, and I'm really happy that I'm part of the Ojibwe."

    Sabe has one eye, a sensor that detects movement and lets it know to start listening.

    Close-up of three small robots on a table.
    Hoy's Sabe, or Bigfoot, SkoBot on display (right), alongside three other SkoBots that Boyer brought with her to show off at the STEAM Museum. Each represents a specific animal: a wolf, turtle and bear. Hoy's SkoBot is 3D printed in light gray, and its face is adorned with a footprint surrounded by floral designs.
    (
    Kadin Mills
    /
    NPR
    )

    "Basically, when it hears that one trigger word, it then plays a prerecorded audio file. So there isn't synthetic speech, there isn't any generative AI," said Boyer. "It's simply listening to what you're saying, identifying it and playing [audio files] that already exist."

    That means the SkoBots will never make things up, often called AI hallucinations. Hoy said it's important not to use generative AI. "AI tends to falsify things a lot, not get things from trustworthy sources."

    Boyer's goal isn't to replace interactions with real language speakers. Instead, it's to get kids interested in not only their languages, but in subjects like science, math and engineering as well. That includes getting them to think about how to use AI ethically.

    "Artificial intelligence, especially when it's not created by Indigenous people, stands to do a lot of harm to our communities," she said. "When you are putting accurate information into these models … you're giving away sacred information to companies that don't have our best interests at heart."

    And as chatbots have become more popular, Boyer said some people have turned to them to help them learn their languages. She's even seen large language models like ChatGPT invent fake words in Anishinaabemowin, which she said is dangerous. "If we're not learning our language correctly, we shouldn't learn it at all."

    Jocelyn Hoy is Holden's mom. She's excited that her son is not only exposed to their culture, but he's eager to know more. She said he's even been teaching her new things.

    "As someone who, at a time in my life, did not want to be identified as Native American … now as an adult, I cannot wait to learn more, and I think the SkoBots are going to help me and so many kids — so many people in general — learn their heritage and who they are."

    Holden Hoy said that heritage and the language are inseparable: "The language is the culture!"

    He added, "It is important to protect it, because it's some people's way of life. Generation after generation is based around this culture."

    Edited by: Steve Drummond and Lauren Migaki
    Visual design and development by: LA Johnson
    Copyright 2026 NPR

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  • Artist brings Korean public art tradition to Ktown
    A tall affordable-housing building with a mural covering its upper side wall. The mural depicts Korean drummers in traditional dress mid-performance beneath sweeping ribbons of color, with green mountains and faint architecture in the background and large pink plum blossoms across the lower portion. Green trees and a peaked rooftop are in the foreground under a clear blue sky.
    Artist Dave Young Kim's mural at the Korean Resource Center in Koreatown depicts traditional Korean drummers. The mural was informed by oral histories collected by youth in the Koreatown Storytelling Program.

    Topline:

    Korean American artist Dave Young Kim has completed his first mural in Koreatown, aiming to revive a tradition of Korean public art that has largely disappeared from the neighborhood where he grew up.


    The mural: Installed this summer at the Korean Resource Center, the mural centers on pungmulnori — a traditional Korean folk performance combining drumming, dance and acrobatics — with drummers moving beneath sweeping ribbons of color and plum blossoms blooming across the wall.

    Why it matters: Kim, 46, who was born and raised in Koreatown, says many of the culturally rooted murals he remembers from childhood have vanished, along with the public funding that once supported them. His work carries forward a tradition established by Korean American muralists like Dong-In Park in the late 1980s and early 1990s — at a time when longtime residents worry the neighborhood's Korean character is fading amid rapid change.

    This story first appeared on The LA Local.

    Murals depicting Korean drummers, dancers and historical figures were a large part of Dave Young Kim’s childhood in Koreatown.

    At the time, the Korean American artist didn’t know what all of the imagery meant, but it left a lasting impression on him.

    “We don’t learn culture via formal education. It’s all gleaned,” Kim said. “It’s just what we sense, and we feel a connection to it without actually knowing anything about it. It belongs to us, and it feels very familiar.”

    Many of the murals Kim remembers from his childhood have since disappeared. With his latest mural at the Korean Resource Center, Kim hopes to bring some of that visual imagery back to the neighborhood.

    Completed this summer, the mural is Kim’s first in Koreatown.

    The mural shows a group of traditional Korean drummers moving beneath sweeping ribbons of color, with plum blossoms blooming across the bottom of the wall. Faint outlines of traditional Korean architecture appear in the background.

    At the center of the mural is 풍물놀이 (pungmulnori), a traditional Korean folk performance that combines drumming, dance and acrobatics and has long been part of village festivals and celebrations.

    A close-up of the mural showing five Korean drummers in traditional white and black dress with yellow, blue and red sashes, playing hand drums and gongs. One younger drummer leaps mid-air in white sneakers. Faint outlines of traditional Korean architecture appear behind them, with pink plum blossoms blooming across the bottom.
    A close-up view of artist Dave Young Kim’s mural at the Korean Resource Center in Koreatown. The work depicts traditional Korean drummers.
    (
    Courtesy Dave Young Kim
    )

    For Kim, the project was a chance to reconnect the neighborhood with the kind of cultural imagery he says shaped his own understanding of identity growing up.

    “It was important to me growing up, and for me to see myself through very purposeful art, very intentional art,” he said. “For my own formation and identity, I think it was very important. I’d like to do that for future generations.”

    Kim, 46, who was born and raised in Koreatown, said the project felt different from his other murals because it was rooted in the community where he spent his childhood.

    “The formative years of my life are here,” he said.

    The project grew out of the Abbey Mural Prize, a national grant program that supports community-based public mural projects.

    As part of the project, Kim partnered with the Koreatown Storytelling Program, which trains youth to interview community elders. Students interviewed residents at Durae Crenshaw House, an affordable senior housing complex and home to the Korean Resource Center, and shared transcripts with Kim as he developed the mural.

    The architecture in the mural reflects the idea of home that emerged repeatedly in interviews with elders, Kim said.

    “There were a lot of iterations of the mockups. The very initial ones were very, very, very rooted in the stories, the narratives from the elders,” Kim said.

    The interviews also left an impression on Daisy Yeon, 17, one of the students who conducted them. She said participating in the project changed the way she thinks about Koreatown and its history.

    Yeon said she believes traditional Korean imagery still has a place in a neighborhood that has changed rapidly in recent years.

    “Personally, the way Koreatown has evolved in these few last years from the pandemic and the shift where people move into other Korean enclaves like Buena Park and Torrance, Koreatown is partly becoming a place of pop-up matcha spots, for example,” she said. “So I think it’s important for tradition to still be here.”

    Seeing the finished mural was “a full-circle moment,” she said, after spending months interviewing elders whose stories became part of the artwork.

    While researching Koreatown’s public art history, Kim learned many of the murals he saw as a kid grew out of cultural initiatives and public funding that no longer exist. He also discovered an earlier generation of Korean American muralists whose work once covered parts of Koreatown.

    In 1993, artist Dong-In Park completed a mural of traditional Korean farmers’ dance in the Korean Community Center at 981 S. Western Ave.

    He told the Los Angeles Times he hoped “the 1.5- and second-generation Korean kids” would not forget their language and history. Park, along with artists including Sonia Hahn and Kuk Chol Han, helped establish a tradition of public art celebrating Korean culture during the late 1980s and early 1990s.

    A large mural on the side of a building shows Korean drummers and dancers in white traditional dress with red and blue vests performing against a pale blue sky. A central figure leaps mid-dance holding a barrel drum, ribbons streaming from a hat. Korean text and "Korean Community Center" appear at the top right. Below, at street level, are a Mobil gas station, a traffic light and a billboard.
    An undated photo of Dong-In Park’s mural depicting a farmers band playing music and dancing to provide entertainment for Korea’s largely agricultural population. The mural was previously located at 981 Western Avenue in Koreatown.
    (
    Courtesy Mural Conservancy of Los Angeles
    )

    Kim wants his mural to carry that tradition forward while also reflecting the history of the community it was created for.

    The Korean Resource Center, founded by South Korean democracy activist Yoon Han-bong, has long organized around immigrant rights, workers’ rights and civic engagement. During the project, Kim learned that traditional Korean drumming has long played a role in the organization’s activism.

    In the mural, an older drummer who immigrated from Korea leads the group, followed by a middle-aged performer who learned from him and younger drummers wearing sneakers, modeled after college students who continue the tradition today.

    “Where we landed was very much to the core of what KRC is,” Kim said. “They are very activist and progressive.”

    The Koreatown of today is filled with Korean-owned businesses and Korean-language signs, Kim said, but far fewer public murals reflecting Korean culture.

    His latest mural isn’t about recreating the past so much as restoring something he believes has faded from the neighborhood.

    As an artist, Kim said, public art has the power to shape how people experience a place.

    “There’s something about the everyday landscape that you kind of are forced to take in,” he said, “and then as an artist, having the ability to shape what that might be.”

  • Company says "nearly half" of food waste removed
    A picture of the husk of the burned out Lineage Logisitics cold storage facility in Boyle Heights. Demolition equipment can be seen at the edges of the picture.
    Remediation work continues at Lineage Logistics, where residents and nearby businesses have had to deal with odor complaints as rotten food remains inside the ruined cold-storage Lineage Logistics warehouse in Boyle Heights nearly one month after the fire.

    Topline:

    Lineage, the company leasing the storage warehouse in Boyle Heights that burned in June, says “nearly half” the food waste has been removed.

    Why it matters: The rotting food inside the warehouse has led to noxious odors in the surrounding neighborhood, causing issues with vermin.

    The backstory: Lineage has been removing the food products for weeks and has faced citations and warnings from L.A. County and the South Coast Air Quality Management District.

    What's next: Demolition and cleanup of the rest of the burned building will be completed in the coming days, the company said, as it begins cleanup of the unburned section.

    Go deeper: Lineage cleanup by the numbers: Will they meet their deadline?

    Lineage Logistics, the company that operates the burned cold-storage warehouse in Boyle Heights, announced yesterday it's removed “nearly half” of the food waste there.

    The waste, the company said, has been sealed in deodorized containers and is being transported off-site.

    Lineage estimated that demolition and cleanup of the rest of the burned structure should be largely completed in the “coming days.”

    Before the weeklong fire that began on June 17, the warehouse stored approximately 44,000 tons, or 88 million pounds, of food.

    The company said it has started removing the wall separating the burned and unburned sections of the building this weekend to speed up the cleaning of the unburned structure.

    The process includes installing plastic sheeting where the wall used to be to help tamp down odors

    That part could take up to three days and may temporarily increase odors. To mitigate the smell, the company said three carbon filters will be added on the Union Pacific side of the warehouse.

    The company is trying to meet a 45-day deadline set by L.A. Mayor Karen Bass to complete the cleanup. Lineage has faced citations and warnings from L.A. County and the South Coast Air Quality Management District for "an ongoing odor nuisance" and “unsanitary and nuisance conditions.”

  • FDA panel supports widening access

    Topline:

    Advisers to the Food and Drug Administration voted in favor of easing regulation of popular peptides. The recommendations could pave the way for specialized pharmacies to produce them in the U.S.

    Why it matters: Currently, these peptides can't be made in the U.S., except for research purposes, leading many peptide users to buy unvetted substances sold online, with disclaimers such as "for research use only" and "not for human consumption."

    By narrow margins, the panel voted in favor of all but one. The FDA isn't required to follow advisory committee recommendations but typically does.

    A slate of popular peptide therapies has won the backing of a key advisory panel to the federal government — a step that could eventually open up broader access to the experimental drugs.

    In a marathon two-day meeting last week, the panel of doctors, academics and pharmacists recommended the Food and Drug Administration reclassify almost all of the compounds under consideration so that specialized pharmacies in the U.S. could begin offering them.

    Seven different peptide therapies — none of which are FDA-approved drugs — were under consideration.

    Currently, these peptides can't be made in the U.S., except for research purposes, leading many peptide users to buy unvetted substances sold online, with disclaimers such as "for research use only" and "not for human consumption."

    By narrow margins, the panel voted in favor of all but one. The FDA isn't required to follow advisory committee recommendations but typically does.

    The outcome represents a win for Health Secretary Robert F. Kennedy Jr., who has publicly supported peptide therapies, and the broader wellness and longevity industry, which stands to profit substantially.

    These peptides are promoted for a wide range of uses and are often taken together, including for injury recovery, muscle growth and fat loss, improving athletic performance, enhancing metabolism and more.

    If the agency takes the panel's recommendations, clinicians could have the ability to prescribe six peptide therapies: BPC-157, MOTS-c, KPV, TB-500, Epitalon and Semax.

    A compound called Emideltide, sometimes used for insomnia, was the only one to receive a down vote.

    The panel's endorsement of peptides was a striking rejection of the FDA's stance against them.

    While the level of evidence for each compound varies, all of them lack the kind of large, well-controlled trials in humans that are necessary to establish safety and effectiveness, which is required for drug approvals. Peptides are strings of amino acids — smaller than a protein — that often act as signaling molecules in our bodies and carry out many critical functions.

    They can be synthesized and delivered as drugs, often by injection. Some of those, like insulin, are naturally occurring in the body. Others are modified versions, as with the blockbuster GLP-1 obesity drugs.

    Scientists for the agency spoke extensively about the lack of reliable data for any of the seven peptides before the committee. They advised the panel to vote no.

    In some cases, they couldn't find any published clinical studies in humans — and there were safety concerns like the potential to encourage cancer growth or to trigger a massive immune response.

    A "foundational challenge" was simply defining the substances, because the chemical composition for peptides labeled with the same name varied considerably, explained FDA official Russell Wesdyk.

    "You will see many, many different forms," he said. "We can't create quality standards until we actually know what it is."

    The divide among the experts on the panel was a study in contrasts.

    Ahead of the meeting, eight new members were appointed. Most have ties to the peptide industry and include physicians who work for medical practices and companies that promote them.

    In almost all cases, they voted in favor of lifting restrictions.

    A spokesperson for the Department of Health and Human Services pushed back on criticism about potential conflicts of interest and said all underwent the standard ethics and vetting process.

    "I think it's about patient access," said Dr. Asare Christian, one of the panel members who runs a Pennsylvania-based clinic that advertises peptide protocols and hormone optimization.

    That sentiment was echoed throughout the many hours of public comment.

    Compounding pharmacies, large telehealth providers and others from the industry underscored the perils of the unregulated marketplace, with some offering anecdotes of patients obtaining unmarked vials from sketchy suppliers.

    "What we are advocating for is not the Wild West," said Brigham Buhler, who runs a telehealth company that offers hormone optimization and peptides and is an ally of Secretary Kennedy.

    "What we are advocating for is to slow down or shut down the gray and black market and to allow patients to have a safe and effective manufacturing process," he told the panel.

    But some panelists were skeptical of that argument.

    "I'm concerned that we are responding to market-induced demand rather than a decision based in solid science," Dr. Elizabeth Rebello, an anaesthesiologist at the University of Texas MD Anderson Cancer Center, commented after casting a no vote.

    The FDA committee was tasked with reviewing data that supports using these peptides to treat a variety of specific conditions, such as BPC-157 for treating ulcerative colitis, an inflammatory bowel disease.

    However, if the FDA ultimately reclassifies them and they are produced by compounding pharmacies in the U.S., clinicians would have discretion to write prescriptions outside of those narrow indications.

    During the meeting, industry groups — and some on the panel — repeatedly criticized the FDA presentations for not reflecting more recent scientific data on the substances, including results from other human studies that had been submitted ahead of time.

    FDA staff said they had considered everything submitted by the meeting deadline and would still take new information into account as they weigh next steps.

    The decision to place the products on the FDA's official list for compounding doesn't come close to the standards for drug approval, but some worry that nuance will not be clear to the public, which may not be aware of the limited data for humans.

    "I think this endorsement can be potentially harmful and I cannot in good conscience vote yes," said Dr. Brian Lee, a member of the panel and an associate professor at the Keck School of Medicine of USC.

    If the FDA moves to reclassify the peptides so that compounding pharmacies can make them, it will be through a formal rulemaking process that could stretch into next year or 2028. There is a possibility that Kennedy could invoke special authority to make them available sooner.

    The panel is scheduled to meet again in February to consider additional peptide therapies.
    Copyright 2026 NPR