Natasha Lyonne and Jamie Babbit on 'Addicted to Fresno'

Natasha Lyonne (l) and Judy Greer star as co-dependent sisters in, "Addicted to Fresno," by Jamie Babbit.

Natasha Lyonne plays Martha, a cheerful and sunny lesbian, struggling to find the right woman. Judy Greer plays her sister, a jaded and acerbic sex addict who can't seem to help herself from sleeping with every man she meets.

In the new film, "Addicted to Fresno," Natasha Lyonne plays Martha, a cheerful and sunny lesbian, struggling to find the right woman.

Judy Greer plays Martha's sister Shannon, a jaded and acerbic sex addict who can't seem to help herself from sleeping with every man she meets.

It's a turn for Lyonne to play the supportive sibling when, in real life, she struggled with addiction herself.

But the turn stems from her friendship with the filmmaker Jamie Babbit.

They first paired up in 1999 indie film, "But I'm a Cheerleader," about a cheerleader sent by her parents to a special camp to "cure" her of her lesbianism.

The film was a critical hit and Babbit went on to have a busy career directing both film and in TV; she's worked on hit shows like Malcolm in the Middle, Gilmore Girls and Ugly Betty.

"Addicted to Fresno" comes from a very real place to Babbit, too. Her grandmother was a sex addict herself.

Babbit and Lyonne talks with Alex Cohen about the film and the unusual process in which it got produced.