WATCH LIVE: NASA's Artemis II astronauts launch to the moon

Before taking his last steps on the moon, NASA astronaut Gene Cernan made sure to scratch his young daughter's initials into the lunar dust.

He had some parting thoughts for the rest of humanity, too.

"We leave as we came and, God willing, as we shall return, with peace and hope for all mankind," the Apollo 17 commander said before departing for Earth.

That was December 1972. Now, more than half a century later, NASA may be about to fulfill Cernan's wishes.

Watch the launch live stream, set to start at 12:50 p.m. ET, here.

As early as Wednesday at 6:24 p.m., an Orion capsule seated atop a 322-foot rocket will blast off from the Kennedy Space Center in Florida. If all goes according to plan, the capsule will carry four astronauts around the moon and back — sending humans the farthest they've ever been from our home planet.

The mission will be the first launch in the Artemis moon program to include a crew. It follows the uncrewed Artemis I test flight in 2022, which sent an empty Orion capsule on a three-week ride around the moon before splashing down in the Pacific Ocean.

This time, the Artemis II astronauts will first orbit Earth to check out key systems on the spacecraft, and then trace a figure-eight path around our lunar neighbor and back. The entire journey is expected to take just under 10 days.

This mission is a crucial step toward NASA's goal of once again setting foot on lunar soil, and eventually establishing a permanent lunar presence — including a moon base — with the help of international partners.

At a press briefing on Tuesday, Mark Burger, launch weather officer with the Space Force's 45th Weather Squadron, said there was an 80% chance of favorable conditions for launch day, though they were keeping a close eye on the weather.

Jeff Spaulding, senior NASA test director, is a veteran of many launches. He said that for his part, the reality that humans would soon be flying to the moon would probably set in during the final minute before ignition.

"That's when it really starts to hit home that, you know, we really got a shot at making it today," Spaulding said at the briefing. "And I know a lot of people are thinking the same thing, because you can hear a pin drop in that firing room as you count from 10 down to T-zero."

"After that, though," he said with a smile, "it may get a little bit noisier."

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