On Wednesday night California voters will get their only chance to see the two candidates for U.S. Senate meet on the debate stage.

Two Democrats, state Attorney General Kamala Harris and Congresswoman Loretta Sanchez, are running to replace retiring U.S. Senator Barbara Boxer.

It's a historic matchup— an intra-party contest for a Senate seat hasn't happened anywhere in the U.S. in more than 100 years, and this seat hasn't been open since 1992.

But voters? They don't seem that interested. Especially die-hard Republicans, who might find it painful to punch a hole next to a Democratic candidate.

In recent weeks, Sanchez has been ramping up her attacks against Harris, and tonight the two will meet in the one and only scheduled debate at Cal State Los Angeles.

Joining Take Two for a preview:

• Dan Schnur, former candidate for California Secretary of State, and current director of the Jesse M. Unruh Institute of Politics at USC
• Matt Barreto, professor of Political Science and Chicano Studies at UCLA and co-founder of the polling and research firm Latino Decisions