Now, the Partnership for Drug-Free Kids, the same group behind the 1987 egg ad about your brains on drugs, has released a new campaign... no poultry products involved. No words involved actually.
It's made up entirely of emojis.
It's the latest example of how much clout these little images have in our culture these days.
To better understand the evolution of these graphics and their role in how we communicate, we turn to analyst Sharon Ann Lee, founder of Culture Brain - a think tank which focuses on trends.
The campaign, which has already popped up on billboards, magazines and websites, directs viewers to the group's mobile-only site, wegotyou.life, to learn more about the ill effects of drinking and drugs, which aren't communicated in great detail on the ads themselves.
Click on the blue player to listen the interview.